Quality control of ribosomes is critical for cellular function since protein mistranslation leads to severe physiological consequences. We report evidence of a previously unrecognized ribosome quality control system in bacteria that operates at the level of 70S to remove defective ribosomes. YbeY, a previously unidentified endoribonuclease, and the exonuclease RNase R act together by a process ...

Ciprofloxacin is a bactericidal drug which is being used widely throughout the world for the treatment of various bacterial infection. Cytotoxicity and genotoxicity of Ciprofloxacin on human lymphocytes in vitro had been assessed taking various parameters like mitotic index (MI), chromosome aberration (CA), anaphase anomalies, replicative index (RI) and sister chromatid exchange (SCE) as end po...

Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devote...

The high incidence of bacterial infection and the growing resistance of bacteria to conventional antibiotics have resulted in the strong need for the development of new generation of antibiotics. Nano-sized particles have been considered as novel antibacterial agents with high surface area and high reactivity. The overall antibacterial properties of antimicrobial nanostructures can be significa...

The growing problem of antibiotic resistance underlies the critical need to develop new treatments to prevent and control resistant bacterial infection. Exogenous application of bacteriophage lysins results in rapid and specific destruction of Gram-positive bacteria and therefore lysins represent novel antibacterial agents. The PlyC phage lysin is the most potent lysin characterized to date and...

In the last decade, the prevalence and occasional outbreaks of drug-resistant bacteria, such as methicillinresistant Staphylococcus aureus (MRSA) and vancomycinresistant enterococci (VRE), have posed appalling hurdles in the treatment of bacterial infections. New antibacterial agents are, as a result, in desperate demand to combat these pernicious antibiotic-resistant problems that can otherwis...

conclusions over-expression of the synthetic cpc/β protein in the bacterial system (escherichia coli bl-21) showed that e. coli can be used as a basis for further research to produce this desired protein in large quantities. results the sds-page analysis and dot blotting confirmed the production of recombinant c-pc/β in the bacterial expression system. over-expression of cpcb gene was optimized...

plant extracts are rich sources of natural antioxidant and antibacterial compounds. in recent decades, the need for using natural antioxidants in foods, pharmaceuticals and cosmetics has promopted extensive scientific research. the purpose of this study was to investigation of effect of different percentages of rosemary extract (0, 1, 2.5 and 5%) on the quality, chemical and microbial of the pr...

abstract biofilm is a complex community of microorganisms residing within a polysaccharide and/or protein matrix. biofilm can be produced by microorganisms such as bacteria and fungi. both gram positive and gram negative bacteria have this ability. resistance of biofilm to antimicrobial agents is becoming a global issue. bacterial biofilms are important in various aspects such as chronic human ...

Bacterial diseases are an important cause of mortality and morbidity worldwide. The Improper uncontrolled use antibiotics contribute to the bacterial resistance antibiotics.
 It is well known that stop infections by killing or
 
 inhibiting their growth. Antibiotics interfering with critical functions for To overcome this, bacteria developed different mechanisms resist survive. T...