objective(s): biological applications of gold nanoparticles have limitations because of the toxic chemicals used in their synthesis. curcumin can be used as reducing as well as capping agent in synthesis of gnps to eliminate the cytotoxicity. conjugation of curcumin to gold also helps in increasing its solubility and bioavailability. materials and methods: here we report synthesis of gold nanop...

the anti-ischemic effect of aqueous and ethanolic extracts of nigella sativa l. seed was studied using a four-vessel occlusion model in rats. the ischemia was evaluated by optical and transmission electron microscopy. after 20 min of forebrain ischemia, agents were administered intraperitoneally after reperfusion. both extracts comprised an alkaloid. in ischemic rats, the aqueous (1 g/kg) and e...

background: asthma is a chronic inflammatory disorder of the airways. the available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. myrica sapida is known traditionally in...

Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran showed high reactivity to various chemical reagents. 24 products of the prepared compounds chosen tested in (mM) as respectable anticancer factors. The findings revealed that 3b, 6b, 8 widely effective against three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenoca...

artemisia is an important genus of iranian flora whose potent anti-proliferative effect has been demonstrated previously on human cancerous cell lines. in the current study, further fractionation was carried out on the petroleum ether extract of a. aucheri and their cytotoxic effects were evaluated on three human cancer cell lines. cell viability was determined by 3-(4,5-dimethylthiazol-2yl)-2,...

Cancer stem cells (CSCs) are the in a primary tumor that have opportunity to self-renew as well differentiate into certain cell types, thus forming mixed tumor. CSCs been shown be involved every aspect of cancer development, including initiation, proliferation, and metastatic activity; they also chemotherapeutic drug resistance recurrence cancers. Based on these capabilities, explored next targ...

Objective: Cancer has risen as the main cause of diseases with the highest rate of mortality in the world. Drugs used in cancer, usually demonstrate side effects on normal tissues. On the other hand, anticancer small peptides, effective on target tissues, should be safe on healthy organs, as being naturally originated compounds. In addition, they may have good pharmacokinetic properties. carnos...

objective(s): we performed a phase iia clinical trial of trans-1-amino-3-18ffluoro-cyclobutane carboxylic acid (anti-18f-facbc), a synthetic amino acid analog for pet, in patients with metastatic prostate cancer. methods: the study subjects consisted of 10 untreated prostate cancer patients having lymph node and/or bone metastasis. five patients underwent whole-body pet 5 and 30 min after intra...

the current study highlights the in vitro antioxidant and antitumor activity of the previously-synthesized hydrazone derivatives against various free radicals and human cancer cell lines, respectively. the anticancer efficacies of the compound were tested by measuring cytotoxicity in cancer cell lines hela, a549, and non-cancerous nl20 cells. compounds possessing electron-donor methoxy and meth...