Inflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state. The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many ...

Acute pharyngitis is characterized by an inflammation of the mucous membranes in the pharynx. Yanshu spraying agent was prepared according to the traditional Chinese formulation for the treatment of acute pharyngitis. The present study aimed to investigate the anti-inflammatory effect of Yanshu in xylene-induced ear edema in mice and carrageenan-induced paw edema in rats by measuring the degree...

I a comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al. (1) provide evidence in this issue of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception. B1 receptors are generally silent or absent in healthy states and are induced or activated by pathological challenges. When they are absent, as in B1-KO mice, ti...

OBJECTIVE To explore the potential anti-inflammatory and analgesic activities of carboxyamidotriazole (CAI). METHODS A variety of animal models, including the croton oil-induced ear edema, the cotton-induced granuloma, the rat adjuvant-induced arthritis, were used to evaluate anti-inflammatory effect of CAI. Vascular endothelial growth factor (VEGF)--or histamine-stimulated local vascular per...

Arzanol is a novel phloroglucinol α -pyrone, isolated from a Mediterranean plant Helichrysum italicum (Roth) Don ssp. microphyllum which belongs to the family Asteraceae. Arzanol has been reported to possess a variety of pharmacological activities. However, anti-inflammatory, anti-HIV, and antioxidant activities have been studied in some detail. Arzanol has been reported to inhibit inflammatory...

Carboxyamidotriazole (CAI) is a calcium influx inhibitor that is undergoing clinical trials for the treatment of various human cancers following the identification of its antiproliferative and antimetastatic activities. The exact mechanism of its action is not clearly understood, and whether it has other functions besides the established antitumor activity has not been reported either. In the p...

objective: pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. in this study the effects of carvacrol on serum levels of total protein (tp), phospholipase a2 (pla2) and histamine in sensitized guinea pigs was evaluated. materials and methods: sensitized guinea pigs were given drinking water alone (group s), drinking water containing three concentration...

OBJECTIVE To study the anti-inflammatory and analgesic activities of diethyl 1,3-dicyclohexyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate (ZL-5010) in vivo and in vitro. METHODS The analgesic effect of ZL-5010 was evaluated by acetic acid-induced writhing response in mice, and the anti-inflammatory effects was assessed in mice with xylene-induced ear edema and in rats with carrageenan-indu...

purpose: to report a case of severe macular edema following the taking of fingolimod in multiple sclerosis. case report: a 34-year-old woman with a long history of relapsing-remitting multiple sclerosis presented complaining of blurred vision in the left eye that started 1 week before the presentation. she had been taking fingolimod for 4 months. she was not diabetic and had no history of uveit...

Inflammation is a response of vascularized living tissue to the local injury. The severe side effects of steroidal and non-steroidal anti-inflammatory drugs evoked us to search for new anti-inflammatory drugs from the indigenous source. The methanol extract of leaves of Clerodendron infortunatum Linn. (MECI) was evaluated for anti-inflammatory activity against the carrageenan, histamine and dex...