Malaria is still a serious cases all over the world especially in tropical country with predict number 300-500 millions people infected per year. The resistence of these anti-malaria substance make new effort to find strategy against malaria. This study aim summarize potential Piper genus as source antimalarial compound and recent research callus induction piper plant obtain metabolites.The rep...

The TVA has long been held in high esteem for its programs designed to reduce malaria mortality and morbidity rates in the Southeast following its establishment in 1933. One reason why the TVA developed the anti-malaria programs was that they created large bodies of standing water by damming up the Tennessee River and its tributaries. Given the recent increase in river system management project...

Although malaria claims millions of casualties every year there are hardly any recent efforts to model its epidemiology in order to support decision-makers of malaria-control programmes. There have been ample attempts to develop analytical models during the era of WHO malaria eradication programmes (1950-1970), but none of them was detailed enough to honour the high complexity arising from the ...

Malaria remains the leading burden of disease in post-conflict Sierra Leone. To overcome the challenge of anti-malarial drug resistance and improve effective treatment, Sierra Leone adopted artemisinin-combination therapy artesunate-amodiaquine (AS+AQ) as first-line treatment for uncomplicated P. falciparum malaria. Other national policy anti-malarials include artemether-lumefantrine (AL) as an...

INTRODUCTION Home-based management of malaria is promoted as a major strategy for improving prompt delivery of effective malaria treatment in Africa. This study aimed to determine the proportion of children who tested positive for malaria with routine light microscopy among those whose mothers had made a home-based diagnosis in a rural community in Western Kenya. METHODOLOGY This cross-sectio...

Fulani of Mali are known for their lower susceptibility to Plasmodium falciparum malaria than their neighbours, the Dogon, despite similar transmission conditions. However, the mechanisms underlying these differences are poorly understood, particularly those concerning antigenspecific immune responses. The Apical Membrane Antigen 1 (AMA1) and the Merozoite Surface Antigen 1 (MSP1) are two malar...

Drugs are primary weapons for reducing malaria in human populations. However emergence of resistant parasites has repeatedly curtailed the lifespan of each drug that is developed and deployed. Currently the most effective anti-malarial is artemisinin, which is extracted from the leaves of Artemisia annua. Due to poor pharmacokinetic properties and prudent efforts to curtail resistance to monoth...

Background: One of the deadliest parasite infections is malaria. A combination quinine sulphate and doxycycline another therapeutic option for malaria that resistant to chloroquine anticipated be able both combat issue anti-malarial medication resistance as well compliance therapy still raging in certain locations Indonesia. Aim: This study will focus on evaluating possibility interaction betwe...

The production of Interleukin 6 (IL-6) was studied during experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA) infection. IL-6 is present in the serum of mice with ECM, the highest concentrations being observed in mice with full-blown neurological syndrome. High IL-6 levels were also observed, however, in the absence of pathology in nonlethal malaria infection. These dat...

There is intense interest in induction and characterization of strain-transcending neutralizing Ab against antigenically variable human pathogens. We have recently identified the human malaria parasite Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) as a target of broadly neutralizing Abs, but there is little information regarding the functional mechanism(s) of Ab-mediated ...