OBJECTIVE We tested whether antibody screening samples of patients with suspected autoimmune encephalitis with additional research assays would improve the detection of autoimmune encephalitis compared with standard clinical testing alone. METHODS We examined 731 samples (333 CSF, 182 sera, and 108 pairs) from a cohort of 623 patients who were tested for CNS autoantibodies by the University o...

A nti–NMDA receptor (anti-NMDAR) encephalitis was first described in 2007 and is now recognized as one of the most common forms of encephalitis. AntiNMDAR encephalitis is considered a multistage disease, characterized by nonspecific prodromal flu-like symptoms, followed by acute onset of psychiatric manifestations such as psychosis, delusions, hallucinations, anxiety, insomnia, repetitive behav...

Prevalence ofN-Methyl-D-Aspartate Receptor Autoantibodies in the Peripheral Blood: Healthy Control Samples Revisited In March 2013, we published a study in JAMA Psychiatry assessing the prevalence of anti–N-methyl-D-aspartate glutamate receptor (NMDAR) serum autoantibodies in unmedicatedacutely ill patientswith schizophrenia,majordepression (MD), borderlinepersonality disorder (BLPD), and healt...

A 12 years-old boy was admitted in coma without motor deficit, with normal CT scan, CSF with lymphocytosis, and EEG showing B(I)RDS (Figure A). Continuous EEG (24 hours) and subsequent serial intermittent EEGs were performed. Seizures were not documented. Patient developed orofacial diskynesia and coreoathetosis movements affecting superior limbs. Later, EEG showed asymmetric EDB pattern (Figur...