Dynamic constitutional frameworks (DCFs) were synthesized and screened for biofilm inhibition or disruption. They are composed of a trialdehyde core reversibly linked to diamine PEG connector variety neutral, anionic, cationic heads, generate library DCFs multivalent dendritic architectures in the presence Pseudomonas aeruginosa Staphylococcus aureus. The best always polycationic nature heads s...