Bacterial sensitivity and resistivity to any antibiotic tends to undergo temporal fluctuations. The clinical consequence of such behaviour is reduced effectiveness of a particular antibiotic to treat a specific bacterial infection. The forecasting system described in this paper uses a backpropagation neural network to model time series derived from bacteria-antibiotic sensitivity and resistivit...

Background and purpose: Highly consumption of antibiotics and their entrance into the environment has increased concerns all over the world. These compounds enter to the environment through an incomplete metabolism and a considerable amount of them cannot be removed using usual waste filtration systems. Therefore, the present study aimed to investigate the feasibility of using ultraviolet radia...

Evolution of bacteria under sublethal concentrations of antibiotics represents a trade-off between growth and resistance to the antibiotic. To understand this trade-off, we performed in vitro evolution of laboratory Escherichia coli under sublethal concentrations of the aminoglycoside kanamycin over short time durations. We report that fixation of less costly kanamycin-resistant mutants occurre...

Xenodiagnosis by ticks was used to determine whether spirochetes persist in mice after 1 month of antibiotic therapy for vectorborne Borrelia burgdorferi infection. Immunofluorescence and polymerase chain reaction (PCR) were used to show that spirochetes could be found in Ixodes scapularis ticks feeding on 4 of 10 antibiotic-treated mice up to 3 months after therapy. These spirochetes could not...

An important piece of improvement in public health standards, medicine achievements, and development is based on the impressive effect of vaccines and antibiotics on infectious diseases. However, the last three or so decades have witnessed how an unsound use of antibiotics has resulted in antibiotic multi-resistant clones in hospitals and community environments. It also has been said that antib...

The spread of bacteria resistant to antimicrobial agents calls for population-wide treatment strategies to delay or reverse the trend toward antibiotic resistance. Here we propose new criteria for the evaluation of the population-wide effects of treatment protocols for directly transmitted bacterial infections and discuss different usage patterns for single and multiple antibiotic therapy. A ma...

BACKGROUND The production of secondary metabolites with antibiotic properties is a common characteristic to entomopathogenic bacteria Xenorhabdus spp. These metabolites not only have diverse chemical structures but also have a wide range of bioactivities with medicinal and agricultural interests such as antibiotic, antimycotic and insecticidal, nematicidal and antiulcer, antineoplastic and anti...

BACKGROUND Antibiotic treatment options for common infections are diminishing due to the proliferation of antimicrobial resistance (AMR). The impact of Antimicrobial Stewardship (AMS) programs seeking to preserve viable antibiotic drugs by governing their use in hospitals has hitherto been limited. Pharmacists have been delegated a critical role in antibiotic governance in AMS teams within hosp...

In this research, for the first time in Iran, Deferoxamine test for differential diagnosis between Staph. epidermidis and Staph. hominis of other gram­positive cocci is introduced. Besides, the comparative results of the susceptibility rates of Staph. aureus (220 Spp.) and Enterococci ( 110 Spp.) to a new glycopeptide antibiotic (SK&Fl04662) and other 12 antibiotics are presented by Disk-Agar D...

SUMMARY The effect of antibiotic prophylaxis in repeat cesarean section were studied in a prospective, double blind clinical trial. 102 pregnant patients with history of previous cesarean section were studied. The partients entered in two groups; A & B: group A were given 2gr cephalosporin and group B 2gr placebo for 3 dose (IV). From 102 patients 48 pt were in group A and 54 were in group B. ...