BACKGROUND Antibiotics are frequently used in intensive care units (ICUs), and their use is associated with the emergence of bacterial resistance to antibiotics. The aim of this study was to investigate the association between the emergence of Pseudomonas aeruginosa resistance and the duration of antibiotic exposure or mode of administration in an ICU unit. METHODS A 4-year cohort study of in...

Antibiotic resistance can be reduced by using antibiotics prudently based on guidelines of antimicrobial stewardship programs (ASPs) and various data such as pharmacokinetic (PK) and pharmacodynamic (PD) properties of antibiotics, diagnostic testing, antimicrobial susceptibility testing (AST), clinical response, and effects on the microbiota, as well as by new antibiotic developments. The contr...

Antibiotics resistance poses catastrophic threat to global public health. Novel insights into the underlying mechanisms of action will inspire better measures to control drug resistance. Fluoroquinolones are potent and widely prescribed broad-spectrum antibiotics. Bacterial protein degradation pathways represent novel druggable target for the development of new classes of antibiotics. Mycobacte...

n Antibiotics are essential in the prevention and cure of bacterial infections. n The use of antibiotics generates resistance to their effects, reducing their effectiveness in the prevention and cure of disease. n Resistance is associated with antibiotic usage (appropriate or otherwise), and the interaction of microorganisms, people and the environment. n Resistance is therefore not eradicable,...

Recreational waters should be considered as risks for Enterococcal infections in regions with high utilization and long exposure periods. The aim of this study was to investigate the resistance of Enterococci to selected antibiotics and some heavy metals [Pb+2, Fe+2, Zn+2 and Cr+2]. A total of 75 Enterococcal isolates was obtained from 54 bathing and ...

Background: Acne vulgaris is a self-limited disease that mainly involves the sebaceous follicles. Systemic antibiotic is a common therapeutic modality, so bacterial resistance can be a problem. Objectives: Assessment of Propionibacterium resistance to erythromycin, tetracycline, clindamycin and spiramycin. Patients and Methods: Sampling was done on lesions of 123 patients with acne vulgaris who...

BACKGROUND Neonatal sepsis is characterised by bacteraemia and clinical symptoms caused by microorganisms and their toxic products. Gram negative bacteria are the commonest causes of neonatal Sepsis. The resistance to the commonly used antibiotics is alarmingly high. The major reason for emerging resistance against antibiotics is that doctors often do not take blood cultures before starting ant...