Neutral or cationic arene ruthenium complexes providing both hydrophilic as well as hydrophobic properties due to the robustness of the ruthenium-arene unit hold a high potential for the development of metal-based anticancer drugs. Mononuclear arene ruthenium complexes containing P- or N-donor ligands or N,N-, N,O- or O,O-chelating ligands, dinuclear arene ruthenium systems with adjustable orga...

Medicinal and edible mushrooms have been widely used for centuries as nutraceuticals to improve health and to treat numerous diseases. Several species of mushrooms such as Lentinula edodes, Schizophyllum commune, Ganoderma lucidum and Coriolus versicolor have been used as immunostimulators and anticancer agents. Mushroom polysaccharides, as the main active ingredient in the mushroom, belong to ...

A better understanding of the biology and biochemistry of the cancer cell has led to the development of various promising new antineoplastic compounds that are now undergoing phase I, II, and III clinical testing. These drugs include topoisomerase I inhibitors, such as camptothecin and its analogs 9-aminocamptothecin, irinotecan, and topotecan; the paclitaxel analog docetaxel; gemcitabine, an a...

Recent research suggests that mesenchymal stem cells (MSCs) are able to migrate specifically to tumours and their metastases throughout the body. This has led to considerable excitement about the possibility of modifying these cells to express anticancer molecules and using them as specific targeted anticancer agents. However, there are concerns that systemically delivered MSCs may have non-des...

This discussion of structure-activity relationships is confined to two or the more important classes of anticancer agentswthe alkylating agents and the antimetaboliteswand to results obtained with these compounds in experimental animal therapy. An attempt is made to point to correlations between the anticancer activity and the structure of these compounds. From these structure-activity correlat...