A new series of quinazoline-4(3H)-ones are evaluated for anticonvulsant activity. After intraperitoneal (ip) injection to albino mice at a dose of 100 mg/kg body weight, synthesized quinazolin-4(3H)-ones (1-24) were examined in the maximal electroshock (MES) induced seizures and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. The Rotarod method was applied to determine t...

A series of new clubbed aryl oxadiazole-1,2,4-triazine derivatives (6a-l) were designed and synthesized using appropriate chemical routes. The structures to have the required structural elements for any compounds be potential anticonvulsant. Preliminary screening anticonvulsant activity was performed maximal electroshock seizure (MES), subcutaneous pentylenetetrazole-induced (scPTZ) behavioral ...

The anesthetic-sedative barbiturate pentobarbital (PB) and the anticonvulsant barbiturate phenobarbital (PhB) were applied to mammalian spinal cord neurons in primary dissociated cell culture to assess their effects on: (1) postsynaptic GABA-responses; (2) paroxysmal activity produced by the convulsant bicuculline; (3) resting membrane properties; and (4) spontaneous neuronal activity. The resu...

To simulate a convulsive syndrome, phenylcarbamate was administered intraperitoneally at dose of 1 mg/kg. Valproic acid aminoester (43 mg/kg), caramiphene (50 and diferidine (2 mg/kg) were investigated as potential anticonvulsant drugs. Blood brain tissue for the determination acetylcholinesterase (AСhE) taken 10, 30, 60 minutes, 6 24 hours after administration xenobiotic. In case poisoning wit...

Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin-N-Mannich bases of ...

effects of 1,4-butancdiol and related congers compared with those of gamma-hydroxybutyrate and gamma-butyrolactone. Life Sciences 5: 2041-2052, 1966 20. 14. Tate RL, Mehlman MA, Tobin RB: Metabolic fate of 1,3butancdiol in the rat: conversion to beta-hydroxybutyrate. J Nutr 101: 1719-1726, 1971 21. 15. Raskin NH, Sokoloff L: Alcohol dehydrogenase activity in rat brain and liver. J Neurochem 17:...

Background: Enhancement of cerebrocortical GABAergic inhibition is postulated as the main mechanism by which anesthetics inhibit seizures; however this has not been directly tested under controlled conditions. In this study we utilized the isolated cerebral cortex slice preparation and tested the anticonvulsant properties of three anesthetics with differing specificities for GABAergic activatio...

BACKGROUND The purpose of this study was to evaluate the effect of hydrochlorothiazide (HCTZ), a thiazide-type diuretic and an antihypertensive drug, on the anticonvulsant activity of numerous antiepileptic drugs (AEDs: carbamazepine--CBZ, phenytoin--PHT, valproate--VPA, phenobarbital--PB, oxcarbazepine--OXC, lamotrigine--LTG and topiramate--TPM). METHODS The effects of HCTZ and AEDs on convu...

in traditional system of indian medicine, c.bonducella is widely used for its antipyretic, antiperiodic, anticonvulsive, and antiparalytic activities. for assessing anticonvulsant activity, pentylenetetrazole, maximal electro shock, strychnine- and picrotoxin-induced convulsions models were used. diazepam was used as a standard reference for all models except maximal electro shock model, wherei...

Coriandrum sativum L. (coriander) has been indicated for a number of medial problems in traditional medicine such as loss of appetite, convulsion, and nervousness. We have previously shown that the aqueous extract of coriander has depressant effects on motor coordination and spontaneous activity, suggesting of a possible sedative and muscle relaxant effect. These findings suggest that coriander...