Oral antidiabetic drugs (OADs) are used for more than a half-century in the treatment of type 2 diabetes. Only in the last five years, intensive research has been conducted in the pharmacogenetics of these drugs based mainly on the retrospective register studies, but only a handful of associations detected in these studies were replicated. The gene variants in CYP2C9, ABCC8/KCNJ11, and TCF7L2 w...

Invivo Antidiabetic evaluation of Neem leaf extract in alloxan induced ratsShravan Kumar Dholi, Ramakrishna Raparla, Santhosh Mankala, Kannappan Nagappan

Recent decades have seen a resurgent interest in traditional plant treatments for diabetes. This has pervaded nutrition, the pharmaceutical industry and academic research, fuelled by a growing public interest and awareness of so-called complementary and natural types of medicine. Before the advent of insulin therapy in 1922, starvation diets and traditional plant treatments were the cornerstone...

the majority of the antioxidant and antidiabetic activities of fruits are anthocyanins, a group of polyphenolics that are responsible for the color of many fruits, vegetables and flowers. the harvesting time, storage conditions, maturity, extraction steps etc. are very important for the biological activities based on the alteration of chemical composition. the free radical scavenging and antidi...

BACKGROUND Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia generally associated with oxidative stress. The present study aims at evaluating the antioxidant and antidiabetic potential of methanol and hydroethanol extracts of the stem bark and leaves of Pricralima nitida and the Sonchus oleraceus whole plant respectively. METHODS The in vitro antioxidant ac...

BACKGROUND Preclinical evidence suggests a beneficial effect of metformin in colorectal cancer. This study aimed to investigate associations between metformin exposure and colorectal cancer-specific survival using population-level data. METHODS Adult patients with stage I-III colorectal cancer diagnosed from 2001 to 2006 were identified from the National Cancer Registry Ireland. Use of metfor...

Type 2 diabetes is characterized by impaired β-cell function associated with progressive reduction of insulin secretion and β-cell mass. Evidently, there is an unmet need for treatments with greater sustainability in β-cell protection and antidiabetic efficacy. Through an insulin and β cell-independent mechanism, empagliflozin, a specific sodium glucose cotransporter type 2 (SGLT-2) inhibitor, ...

Background: The plant Gmelina arborea has been traditionally used in India for several medicinal purposes like anthelmintic, diuretic, anti-inflammatory, antibacterial and antidiabetic. Aims: The aim of the present study is to explore the anthelmintic and antidiabetic activities of G. arborea bark extracts using ethanol, ethyl acetate, n-butanol and petroleum ether as solvents. Material and met...