The leaves of Ilex kudingcha are used as an ethnomedicine in the treatment of symptoms related with diabetes mellitus and obesity throughout the centuries in China. The present study investigated the antidiabetic activities of an active components group (ACG) obtained from Ilex kudingcha in alloxan-induced type 2 diabetic mice. ACG significantly reduced the elevated levels of serum glycaemic an...

INTRODUCTION People with schizophrenia are at increased risk of developing metabolic disturbances. This risk may be further exacerbated by the use of antipsychotic agents. Research is still ongoing to determine the metabolic impact of antipsychotics on glucose regulation. In this case report we review some of the possible mechanisms of action of antipsychotic medication on glucose regulation. ...

During the last decade, the burst of interest is observed to antidiabetic biguanide metformin as candidate drug for cancer chemoprevention. The analysis of the available data have shown that the efficacy of cancer preventive effect of metformin (MF) and another biguanides, buformin (BF) and phenformin (PF), has been studied in relation to total tumor incidence and to 17 target organs, in 21 var...

Exploration of herbs combination could be an alternative way for developing traditional medicine in order to provide better result or benefits in the therapy of diseases. Andrographis paniculata (Burm. f.) Ness and Gynura procumbens (Lour.) Merr are two medicinal plants that are already well known for traditional treatment of diabetes mellitus (DM). Combination of potent hypoglycaemic effect of...

The purpose of this study was to describe the patterns of antidiabetic medication use and the cost of testing supplies in Canada using information collected by Saskatchewan's Drug Plan (DP) in 2001. The diabetes cohort (n = 41,630) included individuals who met the National Diabetes Surveillance System (NDSS) case definition. An algorithm was then used to identify subjects as having type 1 or ty...

The antidiabetic and antioxidant activity of Ecbolium ligustrinum (family:Acanthaceae) was investigated in alloxan induced diabetic albino rats. A comparison was made between both plant extracts and a known antidiabetic drug Glibenclamide (5mg/kg body weight). The dried flowers of Ecbolium ligustinum was subjected to extraction by continuous hot extraction method using hydroalcohol and chlorofo...

The plant Krameria pauciflora MOC et. Sessé ex DC. is used as an anti-inflammatory and antidiabetic in traditional medicine. The aim of this study was to evaluate the in vivo anti-inflammatory and antidiabetic effects of a methanol extract from the roots of K. pauciflora. Dichloromethane and ethyl acetate extracts obtained by partitioning the methanol extract were also evaluated. Complete metha...

Various types of zinc (Zn) complexes have been developed as promising antidiabetic agents in recent years. However, the pharmacological action of Zn complex is not elucidated because the biodistribution of the complex in a living organism has not been studied. Nuclear medicine imaging is superior technology for the noninvasive analysis of the temporal distribution of drug candidates in living o...

The bark of Ceriops tagal has been used in the Philippines for folk treatment diabetes mellitus (DM). Through an α-glucosidase inhibition assay guided isolation, constituents from detannified methanolic extract were isolated and identified to be methyl 2,4-dihydroxy-3,6- dimethyl benzoate (1), isopimar-7-ene-15S,16-diol (2), betulinic acid (3), lupeol (4), 2,4-dihydroxy-6-methyl (5). Compounds ...