Since current antifungal drugs have not kept pace with the escalating medical demands of fungal infections, new, effective medications are required. However, antifungal drug discovery is hindered by the evolutionary similarity of mammalian and fungal cells, which results in fungal drug targets having human homologs and drug non-selectivity. The group III hybrid histidine kinases (HHKs) are an a...

Considering the tremendous antimicrobial and antifungal potential of medicinally important plants, four important plants used in Indian folklore medicine were chosen to screen their antifungal activity. Leaf extracts of the plants viz. Solanum torvum, Adhatoda vasica, Terminalia chebula and Asparagus racemosus were prepared in organic solvents namely methanol, ethanol and methanol-ethanol (1:1)...

Dandruff caused by Malassezia spp is controlled by antifungal agents. In the present study four medicinal plantsTerminalia bellerica, Terminalia chebula, Emblica officinalis and Lantana camarawere selected to check their antifungal activity. Their efficacy was tested using different concentrations of extracts in various solvents. The antifungal activity of the plant extracts was determined by w...

In this study, 36 extracts derived from 29 plant species selected using an ethnobotanical approach were tested for antifungal activity against a taxonomically diverse group of 13 human pathogenic fungi. We compared the inhibitory characteristics of these plant extracts with those of the commonly used antifungals, amphotericin B and ketoconazole, and the plant-derived antifungal, berberine. Seve...

Brown alga, Turbinaria conoides was successively extracted with n-hexane, cyclohexane, methanol and ethanol:water (1:1). The extracts were evaluated for antibacterial and antifungal activities by disc diffusion method. Minimal inhibitory concentration was determined for active extracts by broth dilution method. The antiviral activity and cytotoxicity of the extracts were tested in human embryon...

The antibacterial agent mupirocin (pseudomonic acid A) is used as a topical agent in the treatment of superficial infections by Gram-positive bacteria, particularly Staphylococcus aureus. However, we demonstrate here that the compound also inhibits the growth of a number of pathogenic fungi in vitro, including a range of dermatophytes and Pityrosporum spp. It inhibited the incorporation of amin...

Dermostatin is a polyene antibiotic which possesses a typical spectrum of antimicrobial activity. In vivo, by parenteral or oral administration, dermostatin was less effective than amphotericin B against Candida albicans. The in vivo activity of dermostatin was comparable to amphotericin B against Cryptococcus neoformans and Blastomyces dermatitidis ; amphotericin B was more effective than derm...

Submit Manuscript | http://medcraveonline.com Superficial fungal infections of the skin, hair, and nails are dermatomycoses that affect the individuals’ health quality of life and are considered a public health issue [1-3]. Dermatological infections affect more than 25% of the people worldwide living in tropical and subtropical regions, mainly individuals involved in outdoor activities, such as...

Since ancient times, folk medicine and agro-food science have benefitted from the use of plant derivatives, such as essential oils, to combat different diseases, as well as to preserve food. In Nature, essential oils play a fundamental role in protecting the plant from biotic and abiotic attacks to which it may be subjected. Many researchers have analyzed in detail the modes of action of essent...

BACKGROUND Cleome gynandra L. (Capparaceae) is an edible weed used in Uganda topically for its presumed antifungal activity against Tinea capitis. The goal of this study was to determine if this plant possesses antifungal activity in vitro, since T. capitis is a pervasive infection among especially rural children. METHODS Antifungal activity assay was performed by Broth dilution method, and t...