Reproducibly differential responses to different classes of antihypertensive agents are observed among hypertensive patients and may be due to interindividual differences in hypertension pathology. Computational models provide a tool for investigating the impact of underlying disease mechanisms on the response to antihypertensive therapies with different mechanisms of action. We present the dev...

Aortic barorecptor function was studied in spontaneously hypertensive rats (SHR) of various ages and normotensive Wistar rats. The aortic arch was isolated and perfused, and the activity of the left aortic nerve was recorded. The threshold pressure to elicit barerecptor firing was 80-120 mmHg in normotensive Wistar rats. Resetting of barorecptors (threshold pressure 160-180 mmHg) was found in a...

A series of substituted 2-piperidino-4-amino-6,7-dimethoxyquinazolines was synthesized and screened as potential antihypertensive agents. The hypotensive effect of all the new compounds was studied after intravenous administrations in urethane-anesthetized normotensive rats. The furoylpiperazine moiety in the prazosin molecule could be replaced by a more stable substituted piperidine group with...

Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...

Background Diabetes mellitus (DM) and primary aldosteronism (PA) have been reported to induce drug-resistant hypertension and atherosclerosis. It is likely that blood pressure (BP) control becomes far more difficult in PA patients with DM. However, precise clinical characteristics of PA with type 2 DM especially in the aspect of BP control are not clear. Methods The study included 18 patients...

In patients with hypertension, 24-hour blood pressure control is the major therapeutic goal. The number of daily doses is one characteristic of an antihypertensive agent that may affect the adequacy of 24-hour control. One measure of therapeutic coverage is the 24-hour trough-to-peak ratio, which determines the suitability of an agent for once-daily administration. The closer an agent is to a 1...

Resistant hypertension, defined as failure to achieve target blood pressure despite the use of optimal or maximum doses of at least 3 agents, one of which is a diuretic, or requiring 4 or more medications to achieve blood pressure goal, is likely to affect up to 20% of all patients with hypertension. Apparent resistant hypertension may be caused by medication nonadherence, substances that eithe...

Background Refractory hypertension (RfH) is a severe phenotype of resistant (RH) linked to higher risk stroke and other adverse cardiovascular events, but knowledge about it still lacking. Objectives To evaluate the association between RfH stroke. Methods We conducted cross-sectional study in referral clinic for patients with period from 2018 2020. RH was defined as uncontrolled blood pressure ...

Background Arterial stiffness and hypertension are strong predictors of cardiovascular disease mortality. Angiotensin-converting enzyme inhibitors (ACEI) angiotensin receptor blockers (ARB) first-line antihypertensive agents in reducing blood pressure arterial stiffness. Objective The objective this study was to compare the effects ACEI ARB preventing target organ damage patients with hypertens...

Medication nonadherence is a public health epidemic. Numerous studies evaluating a wide variety of drugs and conducted in varied healthcare settings have described the consistent nature of this problem.1 Hypertension is no exception: Almost half of patients become nonadherent to their antihypertensive medication within 1 year of initiating therapy.2 Although difficult to quantify precisely,3 th...