نتایج جستجو برای: antineoplastic agents
تعداد نتایج: 363533 فیلتر نتایج به سال:
Antineoplastic drugs (ANPDs) are a heterogeneous group of chemicals that include alkylating agents (e.g., cyclophosphamide, melphalan, chlorambucil), antimetabolites (e.g., thioguanine, 5-fluorouracil, methotrexate), antibiotics (e.g., doxorubicin), mitotic spindle inhibitors (e.g., vincristine), hormones (e.g., diethylstilbestrol, free radical generators (e.g., bleomycin) and topoisomerase inh...
Exposure of health care workers to antineoplastic drugs and subsequent adverse health effects is still an open issue. Very little has been studied on the extent of occupational exposure and handling conditions of antineoplastic drugs in Iran. We aimed to determine cyclophosphamide and ifosfamide concentrations in the urine samples of oncology healthcare workers. In addition, we assessed workpla...
Department of Healthcare-Associated Infection and Antimicrobial Resistance, Health Protection Agency Centre for Infections, London NW9 5EQ, UK; Immunisation Department, Health Protection Agency Centre for Infections, London NW9 5EQ, UK; Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, London NW9 5HT, UK; Respiratory and Systemic Infectio...
PURPOSE Primary tumor growth is usually assessed by measuring tumor mass or volume, under the assumption that such variables correlate with the contents of tumor cells. However, tumors are complex interacting mixtures of tumor cells and host components. The different sensitivity of such components to cytostatic agents should be taken into consideration when evaluating the effectiveness of antin...
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Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro.
Telomerase activity is frequently associated with the malignant phenotype, and it can be considered an almost ubiquitous tumor marker. In this study, we evaluated telomerase activity in telomerase-positive human tumor cell lines exposed in vitro to antineoplastic agents. The results show that drug-induced cell killing of tumor cells is associated with a decline in detectable telomerase activity...
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