skin and hair, and is synthesized in melanosomes transferred from melanocytes. Although melanin plays an important protective role against UV light, over production and accumulation of melanin pigment it could create serious skin problems such as freckles, age spots, and melasma. Thus, the inhibition of melanogenesis has been the focus of medicinal and cosmetic treatments for skin depigmenting ...

The covalent modifications of sulfhydryl groups (-SH) may occur through oxidation to mixed disulfides (S-thiolation), S-nitrosylation, as well as persulfide and trisulfide formation. The latter possibilities of -SH group modification connected with compounds containing sulfur called sulfane sulfur are described in this paper. Sulfane sulfur compounds contain a labile, highly reactive sulfur ato...