Background—The antiplatelet effect of aspirin is attributed to platelet cyclooxygenase-1 inhibition. Controversy exists on the prevalence of platelet resistance to aspirin in patients with coronary artery disease and effects of aspirin dose on inhibition. Our primary aim was to determine the degree of platelet aspirin responsiveness in patients, as measured by commonly used methods, and to stud...

BACKGROUND The antiplatelet effect of aspirin is attributed to platelet cyclooxygenase-1 inhibition. Controversy exists on the prevalence of platelet resistance to aspirin in patients with coronary artery disease and effects of aspirin dose on inhibition. Our primary aim was to determine the degree of platelet aspirin responsiveness in patients, as measured by commonly used methods, and to stud...

BACKGROUND Recent studies suggest that the inflammation-associated protein calprotectin may be implicated in the pathogenesis of coronary artery disease (CAD). However, the impact of calprotectin levels on platelet aggregation in CAD patients has never been investigated. OBJECTIVES We investigated the association between calprotectin levels and platelet aggregation in stable, high-risk CAD pa...

The f3-adrenergic antagonist propranolol has been found to inhibit platelet aggregation. We investigated the possibility that propranolol exerts this action by stimulating the synthesis or enhancing the antiaggregatory activity of prostaglandin (PG) 12. The media from cultures of human endothelial cells inhibited thrombin-induced platelet aggregation, an effect attributed to PGI2 production by ...

BACKGROUND After addressing fundamental questions in preclinical models in vitro or in small animals in vivo, the translation into large animal models has become a prerequisite before transferring new findings to human medicine. Especially in cardiovascular, orthopaedic and reconstructive surgery, the sheep is an important in vivo model for testing innovative therapies or medical devices prior ...

In recent years, much of the momentum in stroke prevention has been generated by the substantial risk reduction than can be achieved by carotid endarterectomy for severe carotid disease [1] and warfarin for non-valvular atrial fibrillation [2]. These landmark trial results have perhaps overshadowed the importance of antiplatelet therapy as a mainstay of stroke prevention, since the value of asp...

BACKGROUND Studies performed in Anglo-Saxon countries show that 5% of patients are resistant to the antiplatelet effects of aspirin. AIM To assess the prevalence of aspirin resistance in a sample of Chilean cardiovascular patients and its association with clinical and laboratory characteristics. PATIENTS AND METHODS Ninety nine patients (30 women, 63+/-10 years) treated for stable cardiovas...