The present study shows the putative antiproliferative mechanism of action previously analytically characterized nudibranch extract ( Dolabella auricularia, NB) and its different effects in colon cancer cells vs. nontumor cells. NB increased accumulation reactive oxygen species (ROS) endoplasmic reticulum (ER) stress via stimulation unfolded protein response. Stress scavengers, N-acetylcysteine...

There is a strong drive worldwide to discover and exploit the therapeutic potential of a large variety of plants. In this work, an alcoholic extract of Helleborus purpurascens (family Ranunculaceae) was investigated for the identification of amino acids and peptides with putative antiproliferative effects. In our work, a separation strategy was developed using solvents of different polarity in ...

Studies have been aimed at the establishment of structure-activity relationships that define choline kinase inhibitory and antiproliferative activities of 40 bisquinolinium compounds. These derivatives have electron-releasing groups at position 4 of the quinolinium ring. It is found that the enzymatic inhibition is closely related to the size of the linker, the 3,3'-biphenyl moiety being the mo...

BACKGROUND Haematoxylum brasiletto is a tree that grows in Central America, commonly known as "Palo de Brasil," which is used in the traditional medicine for the treatment of cancer and gastric ulcers. OBJECTIVE The aim of this study was to isolate the compounds responsible for antiproliferative activity of H. brasiletto. MATERIALS AND METHODS A bioassay-guided fractionation of ethanol extr...

Abstract In this study, antioxidant, oxidant, antimicrobial, and antiproliferative activities of Asparagus acutifolius L. officinalis L., known for their nutritional properties, were determined. context, methanol (MeOH) dichloromethane (DCM) extracts plants obtained. Total antioxidant status (TAS), total oxidant (TOS), oxidative stress index (OSI) determined using Rel Assay kits. Antimicrobial ...

AIM 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (M1) was synthesized and evaluated for in-vivo antiproliferative action in diethylnitrosamine-induced hepatocarcinogenic rats. MATERIALS & METHODS The antiproliferative effect of M1 was assessed by various biochemical parameters, histopathology of liver and HPLC analysis. Proton nuclear magnetic resonance-based serum metaboli...