We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of t...

Anterior scleritis and episcleritis are a well-known presentation in tuberculosis. The case of a female patient with presumed tuberculous anterior scleritis and episcleritis is discussed in this article. Anterior segment OCT was efficient in diagnosis and evaluation of the therapeutic outcome. Antituberculosis chemotherapy was sufficient to achieve clinical remission.

A novel series of sulpha/ substituted phenyl azo indoles is synthesised by the condensation reaction of N.phenacyl sulpha/ substituted phenyl amine with diazonium salt of sulpha/substituted benzene. They were characterized by IR, NMR and UV spectra and screened for their promising antituberculosis activity and antifertility activity. Keyword: indoles, sulpha/ substituted, drug, biological activ...

Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion ...

Paragonimiasis is a disease which is frequently misdiagnosed as pulmonary tuberculosis. In the areas where people eat crab/crayfish this disease should be considered in the differential diagnosis to avoid antituberculosis treatment for a non-tubercular condition. We are reporting a case of pulmonary paragonimiasis who had been treated for tuberculosis.

Adult respiratory distress syndrome (ARDS) is a rare but severe complication of miliary tuberculosis, which may appear even after introduction of antituberculosis therapy. Mortality has been reported to be as high as 100% if there is associated pancytopenia. We report a case of a patient infected with the human immunodeficiency virus who presented with miliary tuberculosis associated with pancy...

It was shown that 5-chloro-8-hydroxyquinoline, an antituberculosis agent, gels aqueous alcohol solutions efficiently. Thermal stability and gel-to-sol transition temperature of 1% gel in CD₃OD/D₂O (2:1) was studied by ¹H-NMR. Fibrous structures of four xerogels have been characterized by scanning electron microscope.

The Sensititre MycoTB plate (TREK Diagnostic Systems, Cleveland, OH) uses a microtiter plate MIC format for susceptibility testing of Mycobacterium tuberculosis complex isolates against first- and second-line antituberculosis agents. Categorical agreement versus the agar proportion method for 122 M. tuberculosis complex isolates was 94% to 100%.

Background Severe oxidative stress has been reported in tuberculosis [TB] patients. There are no previous reports regarding oxidative stress index and supplementation of antioxidants in TB. The objective of this study was to assess the antioxidant status, lipid peroxidation and oxidative stress index in TB patients. Also to assess the antioxidant supplementation with antituberculosis therapy in...

Isoniazid is the most important antituberculosis medicine. Adverse effects are generally fever and rash. There are few case reports in the literature which identified high fever without rash associated with INH use. In this case report, we present a case with tuberculosis lymphadenitis and isoniazid-induced fever.