Evaluation of sources of pharmacokinetic variation can facilitate optimization of tuberculosis treatment regimens by identification of avoidable sources of variation and of risk factors for low or high drug concentrations in patients. Our objective was to describe the pharmacokinetics of rifampin, isoniazid, pyrazinamide, and ethambutol in a cohort of tuberculosis patients established on first-...

BACKGROUND The incidence of tuberculous pericarditis is increasing in Africa as a result of the human immunodeficiency virus (HIV) epidemic. The primary objective of this article was to review and summarize the literature on the pathogenesis, diagnosis, and management of tuberculous pericarditis. METHODS AND RESULTS We searched MEDLINE (January 1966 to May 2005) and the Cochrane Library (Issu...

The hepatoprotective properties of Alchornea cordifolia, a medicinal plant was studied in hepatotoxicity induced animal model with high dose paracetamol or carbon tetrachloride. Knowing that antituberculosis drugs also represent risk factor for hepatotoxicity, could A. cordifolia play key role to limit their hepatotoxicity? objective this study assess the histological changes rat livers and evo...

Abstract Antituberculosis drug‐induced liver injury (ATDILI) has received increasing attention globally, which may limit the effectiveness of antituberculosis (anti‐TB) treatment. Many host genetic determinants ATDILI have been identified recently. As little knowledge is currently available about association between aldehyde dehydrogenase 1 family member A1 (ALDH1A1) polymorphisms and ATDILI, t...

BACKGROUND MDR Mycobacterium tuberculosis is the major cause of treatment failure in tuberculosis patients, especially in immunosuppressed. We described a young polymyositis patient on immunosuppressive therapy who was started with antituberculosis therapy as a susceptible strain of M. tuberculosis was isolated from a single cutaneous abscess in his neck and from regional lymph nodes. CASE PR...

BACKGROUND The incidence of tuberculosis is high in Africa. It is treated with medications that can trigger neuropathic pain and thus negatively affect patients' quality of life and treatment compliance. The aim of this study was to investigate neuropathic pain due to antituberculosis drugs in patients without HIV infection. METHODS This prospective study, conducted in the pulmonology departm...

(Thiazolyl-2-yl)hydrazones (THs) are a group of organic compounds containing both hydrazone and 1,3-thiazole pharmacophores present in many approved drugs. They have been investigated greatly recent years due to potent anticancer, antibacterial, antifungal, antituberculosis, anti-inflammatory, antiparasitic activities. In this study, one pyridine-based two quinoline-based, novel THs were synthe...

Nervous system toxicity with current antituberculosis pharmacotherapy is relatively uncommon, although the frequency of the usage of antituberculosis therapy requires that physicians should be aware of such toxicity. Peripheral neuropathy is a rare adverse effect associated with isoniazid, and it occurs after the prolonged use of this drug [1]. This usually presents with paresthesias which can ...

PURPOSE The aim of this study was to evaluate the ability of the NBT reduction by non- and BCG-stimulated monocytes isolated from peripheral blood persons with pulmonary tuberculosis (TB) before treatment, after two-month antituberculosis therapy and in an inactive stage of this disease. MATERIAL AND METHODS The spontaneous and induced NBT tests were done in 24 healthy individuals and 59 pati...