The cornea remains in a state of deturgescence, maintained by endothelial cell Na+/K+ ATPase and by tight junctions between endothelial cells that limit entrance of fluid into the stroma. Fuchs' endothelial corneal dystrophy (FECD) was initially described by Fuchs in 1910 as a combination of epithelial and stromal edema in older patients. It manifests as bilateral, albeit asymmetric, central co...

Congenital hereditary endothelial dystrophy (CHED) is a rare autosomal recessive disorder of the corneal endothelium characterized by nonprogressive bilateral corneal edema and opacification present at birth. Here we review the current knowledge on the role of the SLC4A11 gene, protein, and its mutations in the pathophysiology and clinical presentation of CHED. Individuals with CHED have mutati...

choice to try a new potent medication once a day instead of his current 2 medications, the patient elected to try travoprost once daily beginning on January 3. Two days later, he called complaining of mild redness, discomfort, andblurriness.Hewasadvised of an adjustment period with this eyedrop and told to call back if symptoms did not improve. His symptoms worsened, and by January 8, his visua...

In phacoemulsification, ultrasound induces hydroxyl radical (·OH) formation, damaging corneal endothelium. Whether H2 can prevent such oxidative damage in phacoemulsification was examined by in vitro and in vivo studies. H2 was dissolved in a commercial irrigating solution. The effects of H2 against ·OH generation were first confirmed in vitro by electron-spin resonance (ESR) and hydroxyphenyl ...

BACKGROUND Congenital hereditary endothelial dystrophy (CHED) is an autosomal recessive disorder characterized by bilateral, symmetrical, noninflammatory corneal clouding (edema) present at birth or shortly thereafter. This study reports on an unusual delayed presentation of CHED with compound heterozygous SLC4A11 mutations. MATERIALS AND METHODS A 45-year-old female, presenting with bilatera...

Background: The 1ry indication for scleral fixation of intraocular lenses (IOL) is dislocation as a principal complication of cataract surgery. Inadequate capsular support is the most common cause of IOL dislocation. Other indications include traumatic phakic lens dislocation (cataractous or clear), surgically aphakic eyes or anterior chamber IOL with complications (persistent hyphema, uveitis)...

Corneal touch thresholds (CTT) were measured in 30 non-pregnant women serving as a control group and 29 pregnant women at different times during and after pregnancy. The results show that CTT becomes significantly higher after 31 weeks of pregnancy. However, only 86% of the subjects showed a difference in CTT during and after pregnancy, while 52% reported having some swelling. The loss of sensi...

THiE problem of correcting the refractive error of an aphakic eye other than by prescribing the cumbersome cataract lenses still remains open, in spite of the excellent work done in this field by Ridley, and all its modifications. In search of a method which might combine greater safety for the patient with a simpler operative technique, an operation has been devised which consists in implantin...