Wound healing in the inner ear sensory epithelia is performed by the apical domains of supporting cells (SCs). Junctional F-actin belts of SCs are thin during development but become exceptionally thick during maturation. The functional significance of the thick belts is not fully understood. We have studied the role of F-actin belts during wound healing in the developing and adult cochlea of mi...

statement of problem: endodontic treatment of necrotic teeth with open apices is a challenge. after ruling out surgery as a treatment scheme and introduction of the multivisit apexification which in turn had its disadvantages, apical plug seems to be a suitable substitute treatment plan for such cases. apical plug makes the treatment through formation of a barrier against the obturating materia...

Gomes, Pedro, and Patrı́cio Soares-da-Silva. Upregulation of apical NHE3 in renal OK cells overexpressing the rodent 1-subunit of the Na pump. Am J Physiol Regul Integr Comp Physiol 290: R1142–R1150, 2006. First published November 17, 2005; doi:10.1152/ajpregu.00102.2005.— Vectorial Na reabsorption across the proximal tubule is mediated by apical entry of Na , primarily via Na /H exchanger isofo...

AIM Mineral trioxide aggregate (MTA) is the material of choice for apical barrier techniques during root canal treatment of teeth with open apices. However, the precise control of MTA during the placement of an apical plug is challenging. This article describes the outcomes of unintentional extrusion of MTA into the periradicular tissue during apical barrier treatment in three cases. SUMMARY ...

Kidney proton-secreting A-intercalated cells (A-IC) respond to systemic acidosis by accumulating the vacuolar ATPase (V-ATPase) in their apical membrane and by increasing the length and number of apical microvilli. We show here that the cell-permeant cAMP analog CPT-cAMP, infused in vivo, results in an almost twofold increase in apical V-ATPase accumulation in AE1-positive A-IC within 15 min an...

Objective: The aim of this study was to compare the amounts debris extruded apically with use different single file systems during endodontic retreatment. Material and Methods: 36 mandibular premolar teeth were prepared ProTaper Universal files up F3. At every instrument change, root canals irrigated 2 mL 5.25% NaOCl solution. After canal preparation, final irrigation performed using 5 17% EDTA...