Recent developments on the Web are marked by the growing support for the Linked Data initiative, which encourages government and public organisations, as well as private institutions, to expose their data on the Web. This results in a plentitude of multi-lingual document collections where the original resources are published in the language, in which they are available. The challenges of multil...

In the fruitfly Drosophila melanogaster, the differential development of wing and haltere is dependent on the function of the Hox protein Ultrabithorax (Ubx). Here we compare Ubx-mediated regulation of wing patterning genes between the honeybee, Apis mellifera, the silkmoth, Bombyx mori and Drosophila. Orthologues of Ubx are expressed in the third thoracic segment of Apis and Bombyx, although t...

Western honey bees (Apis mellifera) face an increasing number of challenges that in recent years have led to significant economic effects on apiculture, with attendant consequences for agriculture. Nosemosis is a fungal infection of honey bees caused by either Nosema apis or N. ceranae. The putative greater virulence of N. ceranae has spurred interest in understanding how it differs from N. api...

To accelerate the molecular analysis of behavior in the honey bee (Apis mellifera), we created expressed sequence tag (EST) and cDNA microarray resources for the bee brain. Over 20,000 cDNA clones were partially sequenced from a normalized (and subsequently subtracted) library generated from adult A. mellifera brains. These sequences were processed to identify 15,311 high-quality ESTs represent...

The constant improvement and falling prices of whole human genome Next Generation Sequencing (NGS) has resulted in rapid adoption of genomic information at both clinics and research institutions. Considered together, the complexity of genomics data, due to its large volume and diversity along with the need for genomic data sharing, has resulted in the creation of Application Programming Interfa...

We have determined distinct roles for different proteasome complexes in adenovirus (Ad) E1A-dependent transcription. We show that the 19S ATPase, S8, as a component of 19S ATPase proteins independent of 20S (APIS), binds specifically to the E1A transactivation domain, conserved region 3 (CR3). Recruitment of APIS to CR3 enhances the ability of E1A to stimulate transcription from viral early gen...

Greater virtual machine density ............................................................................................................. 3 Performance and reliability features ................................................................................................... 4 Queue depth throttling ..............................................................................................

Conventionally, damaged and ubiquitinated proteins are subjected to degradation in the 26S proteasome in eukaryotes. However, several observations have indicated that the 19S subcomplex of the 26S proteasome may play a non-proteolytic role in RNA polymerase II (Pol II) transcription 1 : (1) Ubiquitination was thought to be required for activity of a viral transcription activator, VP16. (2) The ...

Aiming to contribute drug pre-formulation, new eutectic mixtures were developed. Thymol, coumarin, or quaternary ammonium chlorides as excipients, combined with the active pharmaceutical ingredients (APIs) acetylsalicylic acid, acetaminophen, ibuprofen, ketoprofen, lidocaine. Their solid-liquid equilibrium (SLE) binary phase diagrams measured study eventual separation between compounds, prevent...