Eleven of twenty-four patients with severe aplastic anemia given marrow grafts from HLA-identical siblings between October 1970 and March 1973 are alive with normal marrow function and continued evidence of engraftment 3-5 yr later. Ten have been leading normal lives with no immunosuppressive or other drug therapy since day 100 postgrafting. One has had chronic graft-versus-host disease of the ...

A study of the occurrence of aplastic anemia among atomic bomb survivors in Nagasaki and Hiroshima, Japan was made from a review of a series of 6327 autopsies from 1949 to June 1967 and the late effects of ionizing radiation were evaluated. There were 340 cases reviewed independently by a team of hematologists and pathologists. Of the 45 cases documented as aplastic anemia, 42 were definite and...

Andrea Bacigalupo has recently published very useful guidelines for the treatment of severe aplastic anemia. As in the most recent and authoritative monograph on this condition, «the empty bone marrow and its devastating consequences for the patient have rightly fascinated hematologists for a century». The term itself is somewhat of a misnomer since the disease consists of a hypo-aplastic pancy...

BACKGROUND In the era of eculizumab, identifying patients with paroxysmal nocturnal hemoglobinuria who may benefit from allogeneic stem cell transplantation is challenging. DESIGN AND METHODS We describe the characteristics and overall survival of 211 patients transplanted for paroxysmal nocturnal hemoglobinuria in 83 EBMT centers from 1978 to 2007. Next, we conducted a comparison with a coho...

OBJECTIVE To determine the clinicohaematological features, treatment and outcome of children diagnosed with aplastic anemia at a single institution. STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY The Aga Khan University Hospital, Karachi, from January 1999 till December 2008. METHODOLOGY Medical records of children aged less than 15 years of age diagnosed with aplastic anem...