Unified Modeling Language (UML) is the Object Management Group (OMG) standard notation for object-oriented modeling. UML activity diagram (AD) are widely used to workflow and system flow in system analysis. However, activity diagram lacks support for simulation, dynamic semantics limits and verifiability capabilities. APN are a popular technique for modeling the control flow dimension of workfl...

For cryptographic applications, the behaviour of the difference map is of importance and since there are no perfect nonlinear (PN) permutations, almost perfect nonlinear (APN) permutations have attracted a lot of attention in the last decades. Costas permutations, which are also extreme with respect to the behaviour of their difference maps, were originally introduced in connection with applica...

this paper deals with the modeling of interaction between agents in Multi Agents System (MAS) based on Agent Petri Nets (APN). Our models are created based on communicating agents. Indeed, an agent initiating a conversation with other can specify the interaction protocol wishes to follow. The combination of APN and FIPA Protocols schemes leads to a set of deployment formal rules for points wher...

Aminopeptidase N (APN; EC 3.4.11.2) purified from Escherichia coli has been crystallized with the optically pure aminophosphinic inhibitor PL250, H(3)N(+)-CH(CH(3))-P(O)(OH)-CH(2)-CH(CH(2)Ph)-CONH-CH(CH(2)Ph)CO(2)(-), which mimics the transition state of the hydrolysis reaction. PL250 inhibits APN with a K(i) of 1.5-2.2 nM and its three-dimensional structure in complex with E. coli APN showed i...

Plasma levels of adiponectin (APN) are significantly increased in patients with renal dysfunction and are inversely related to the risk of cardiovascular mortality. The present study was designed to determine the role of APN in myocardial ischemia-reperfusion (MI/R) injury in mice with renal failure and delineate the underlying mechanisms. Renal failure was induced by subtotal nephrectomy (SN)....

Lee S, Park Y, Dellsperger KC, Zhang C. Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 301: H306–H314, 2011. First published May 20, 2011; doi:10.1152/ajpheart.01306.2010.—Type 2 diabetes (T2D) is a leading risk factor for a variety of cardiovascular diseases including coronary heart dis...

Aminopeptidase N (APN)/CD13 is a widely expressed transmembrane protein and its altered expression has been detected in various cancer cells. Several APN inhibitors have been developed and some of them have been found to have effectiveness as anti-cancer agents. This article reports anti-cancer effects of a hydroxamic acid derivative 24F that was newly-synthesized as an APN inhibitor. 24F had t...

Type 2 diabetes (T2D) is a leading risk factor for a variety of cardiovascular diseases including coronary heart disease and atherosclerosis. Exercise training (ET) has a beneficial effect on these disorders, but the basis for this effect is not fully understood. This study was designed to investigate whether the ET abates endothelial dysfunction in the aorta in T2D. Heterozygous controls (m Le...

Acquired pendular nystagmus (APN) complicates multiple sclerosis and other neurological disorders, causes visual impairment, and is often refractory to available treatments. Vision could be improved by an optical aid that shifts the seen world in lockstep with the APN. An essential component of such a device is the image-shifting mechanism, which must be light, accurate, suitable for battery op...

We derive necessary conditions related to the notions, in additive combinatorics, of Sidon sets and sum-free sets, on those exponents d ∈ Z/(2 − 1)Z which are such that F (x) = x is an APN function over F2n (which is an important cryptographic property). We study to which extent these new conditions may speed up the search for new APN exponents d. We also show a new connection between APN expon...