نتایج جستجو برای: apo e4 polymorphism

تعداد نتایج: 117403  

A Badii AA Moshtaghie H Kharazi M Fazilati T Hassanzadeh

The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture contai...

2014
Hung-Jin Huang Hsin-Yi Chen Cheng-Chun Lee Calvin Yu-Chian Chen

Apolipoprotein E4 (Apo E4) is the major genetic risk factor in the causation of Alzheimer's disease (AD). In this study we utilize virtual screening of the world's largest traditional Chinese medicine (TCM) database and investigate potential compounds for the inhibition of ApoE4. We present the top three TCM candidates: Solapalmitine, Isodesacetyluvaricin, and Budmunchiamine L5 for further inve...

2016
Min Xu Jun Zhao Yu Zhang Xu Ma Qiaoyun Dai Hong Zhi Bei Wang Lina Wang

Objectives. Apo E genes involved in lipoprotein synthesis and metabolism are considered one of the candidates to CHD. However, the results remain conflicting. Methods. We performed this meta-analysis based on 30 published studies including 11,804 CHD patients and 17,713 controls. Results. Compared with the wild genotype E3/3, the variant genotypes ApoEE3/4 and E4/4 were associated with 22% and ...

Journal: :Indian journal of medical sciences 2008
P P Singh M Singh D P Bhatnagar T P Kaur S K Gaur

BACKGROUND The present investigation is aimed at examining the Apolipoprotein E (APOE) genotypic influence on coronary heart disease (CHD) risk in northwest India (Punjab), where this disease is emerging as a major threat to public-health care system. MATERIALS AND METHODS The present study comprised of angiographically diagnosed coronary heart disease patients (n = 193) and controls (n = 150...

Journal: :"Arterial’naya Gipertenziya" ("Arterial Hypertension") 2012

Journal: :The British journal of nutrition 2013
R Chouinard-Watkins C Rioux-Perreault M Fortier J Tremblay-Mercier Y Zhang P Lawrence M C Vohl P Perron D Lorrain J T Brenna S C Cunnane M Plourde

Carrying the apoE ε4 allele (E4+ ) is the most important genetic risk for Alzheimer’s disease. Unlike non-carriers (E4- ), E4+ seem not to be protected against Alzheimer's disease when consuming fish. We hypothesised that this may be linked to a disturbance in n-3 DHA metabolism in E4+. The aim of the present study was to evaluate [13C]DHA metabolism over 28 d in E4+ v. E4-. A total of forty pa...

Journal: :Clinical chemistry 2005
Oliviero Olivieri Nicola Martinelli Marco Sandri Antonella Bassi Patrizia Guarini Elisabetta Trabetti Francesca Pizzolo Domenico Girelli Simonetta Friso Pier Franco Pignatti Roberto Corrocher

BACKGROUND Apolipoprotein C-III (apo C-III) is a marker of cardiovascular disease risk associated with triglyceride (TG)-rich lipoproteins. The T-455C polymorphism in the insulin-responsive element of the APOC3 gene influences TG and apo C-III concentrations. Long-chain n-3 polyunsaturated fatty acids (PUFAs) contained in fish have well-known apo C-III-lowering properties. METHODS We investig...

2014
Faris Yaghmoor Ahmed Noorsaeed Samar Alsaggaf Waleed Aljohani Henrieta Scholtzova Allal Boutajangout Thomas Wisniewski

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer's disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with advancing age being the most prominent. Other environmental risk factors include diabetes mellitus, level...

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