objective(s):pharmacological studies showed that the extracts of jin yin hua and its active constituents have lipid lowering, antipyretic, hepatoprotective, cytoprotective, antimicrobial, antibiotic, antioxidative, antiviral, and anti-inflammatory effects. the purpose of the present study was to investigate the protective effects of caffeoylquinic acids (cqas) from jin yin hua against hydrogen ...

background: calprotectin is cytotoxic agent that its anti-tumor effects are governed through suppression of topoisomerase ii a key enzyme in apoptosis. in previous studies, cytotoxicity and apoptotic effects of calprotectin are shown on different cancer cell lines, but not human gastric cancer cell lines. in the present study, cytotoxicity and apoptotic effects of calprotectin on human gastric ...

BACKGROUND Dexamethasone (DEX) is used for the treatment of various inner ear diseases. However, the molecular mechanism of DEX on gentamicin induced hair cell damage is not known. Therefore, this study investigated the protective effect of DEX on gentamicin (GM)-induced ototoxicity and the effect of GM on the expression of apoptosis related genes. METHODS The protective effects of DEX were m...

Despite common dose–response curves, a compound may have the opposite effect in small doses as in large doses. This phenomenon is named hormesis. Calabrese et al have reported that many toxic substances, environmental hormones, inorganic compounds, and even irradiation induce hormesis. They modulate the growth of cultured cells in a biphasic fashion, either stimulating or inhibiting the growth ...

Treatment of pulmonary arterial hypertension (PAH) has changed with development of PAH targeted therapy, which includes use of specific vasodilator in pulmonary arterial system. Bosentan is an endothelin receptor antagonist (ERA) and vasodilator that was the first approved oral drug for PAH treatment. The clinical benefit of bosentan has been established in several multicenter clinical trials a...

Despite the remarkable advance in medicine and science, the complete cure of neuropsychiatric disorders is still a challenging task. In the aging society, the prevalence of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease has rapidly been increased. The complex relationship of the community members induces serious mental diseases including depression. Increment in ...

OBJECTIVES In this study, we aimed to study the anti-apoptotic effects of hyaluronic acid on the apoptotic effects of bupivacaine in cultured rat chondrocytes in a time and dose-dependent manner. MATERIAL AND METHODS The rat chondrocytes were treated with 7.69 µM, 76.9 µM, and 384.5 µM bupivacaine and 50 µg/ml hyaluronic acid concentrations for six, 24, and 48 hours. At the end of the treatme...

Background and Aims:In neurodegenerative disorders,oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages which can lead to apoptosis. Pro-apoptotic and anti-apoptotic gene expressions are changed during the cell differentiation that affect cell viability and differentiation. Therefore, this study was conducted to determine the effects of hyd...

background: diazinon (dzn) is an organophosphate insecticide widely utilized in agriculture all over the world and causes many negative effects on plants and animal species, especially on human. the aim of present study was to evaluate the effects of dzn on apoptosis of ovarian follicles in adult rats and to assess the protective role of vit e. methods: thirty adult female wistar rats were divi...

This survey was performed to aim of synthesize Nano emulsion from Ferula gummosa essential oil (FEGO-NE) and evaluate its anti-tumor effect. First, analyzed by GC–MS method, then the synthesized as O/W after characterization DLS, Zeta potential, AFM, FESEM TEM methods, toxicity evaluated MTT method. Then pro-apoptotic effects were qPCR (Caspase3, 9, Bax Bcl-2) method AO/PI staining. The cancer ...