نتایج جستجو برای: app rings
تعداد نتایج: 71987 فیلتر نتایج به سال:
The essential metals iron, zinc and copper deposit near the Abeta (amyloid beta-peptide) plaques in the brain cortex of AD (Alzheimer's disease) patients. Plaque-associated iron and zinc are in neurotoxic excess at 1 mM concentrations. APP (amyloid precursor protein) is a single transmembrane metalloprotein cleaved to generate the 40-42-amino-acid Abetas, which exhibit metal-catalysed neurotoxi...
We investigated the relationship between PS1 and gamma-secretase processing of amyloid precursor protein (APP) in primary cultures of neurons. Increasing the amount of APP at the cell surface or towards endosomes did not significantly affect PS1-dependent gamma-secretase cleavage, although little PS1 is present in those subcellular compartments. In contrast, almost no gamma-secretase processing...
In the present work, an extensive theoretical calculation study on Histidine-Histidine dipeptide in gas phase is done by using DFT method with Gaussian 98 program. Through investigations on the molecular geometries of this molecule it is found that there is six rings in the molecules not two rings. The presence of four intramolecular hydrogen bonds is responsible for the formation of additional...
FE65 is an adaptor protein that binds to and forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. The regulatory mechanisms of FE65-APP-mediated transcription are still not clear. In this report, we demonstrate that Dexras1, a Ras family small G protein, binds to FE65 PTB2 domain and potently suppresses the FE65-APP-medi...
We have identified a novel low-density lipoprotein (LDL) receptor family member, termed LDL receptor class A domain containing 3 (LRAD3), which is expressed in neurons. The LRAD3 gene encodes an ∼50 kDa type I transmembrane receptor with an ectodomain containing three LDLa repeats, a transmembrane domain, and a cytoplasmic domain containing a conserved dileucine internalization motif and two po...
Introduction: Intra-cranial references plans used in cephalometry analysis are not considered as stable points and therefore their validity is low however they are widely used. The purpose of conducting this study is to investigate correlation rate of a number of horizontal parameters of extra-cranial with common Horizontal analyses. Methods: In this descriptive and periodic study, lateral ce...
در این مقاله تلاش میشود تبیین و برداشتی متفاوت از ماهیت و کارکرد «سند راهبرد امنیت ملی» مبتنی بر چارچوب کلی رهیافتهای تفسیری و عملگرا[1] در فلسفه سیاست و علوم اجتماعی ارائه شده و بر اساس آن توضیح داده شود که «راهبردیسازی امنیت ملی»[2] و شکلدهی تفسیر و قرائت یگانه[3] و یکپارچه[4] از آن، که در عین حال به ...
The post methods era has witnessed a dramatic change inapproaches to and methods of teaching as well as testing. At the heart of such a change, collaborative learning has received top priority and testing domain has actually gone under scrutiny. This new mode of education has made stakeholders, especially in higher education; reflect on an interactive e-assessment based instruction. Such a cybe...
Introduction: With increasing usage of orthodontic treatments, disinfection of orthodontic appliances and rings is critical for maintaining dental and oral health. Using chemical disinfectants may cause allergic and mucosal disorders. The present study aimed to evaluate Zatariamultiflora essence and to compare it withChlorhexidine (0.2%) mouth wash in controlling experimental plaque from Strept...
In several pedigrees of early onset familial Alzheimer's disease (FAD), point mutations in the beta-amyloid precursor protein (APP) gene are genetically linked to the disease. This finding implicates APP in the pathogenesis of Alzheimer's disease in these individuals. To understand the in vivo function of APP and its processing, we have generated an APP-null mutation in mice. Homozygous APP-def...
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