نتایج جستجو برای: ar 1
تعداد نتایج: 2779340 فیلتر نتایج به سال:
1 This study examines b1-, b2and b3-adrenoceptor (AR)-mediated responses, mRNA levels and radioligand binding in ileum from b3-AR knock-out (7/7) (KO) and wild type (+/+) (FVB) mice. 2 In KO and FVB mice, SR59230A (100 nM) (b3-AR antagonist) antagonized responses to (7)isoprenaline in both KO and FVB mice. (7)-Isoprenaline mediated relaxation of ileum was antagonized weakly by ICI118551 (100 nM...
MUC1 mucin is transcriptionally regulated by estrogen, progesterone, and glucocorticoids. Our objective was to determine whether androgen receptor (AR) activation regulates expression of MUC1. The following breast and prostatic cell lines were phenotyped and grouped according to AR and MUC1 protein expression: 1) AR+MUC1 + [DAR17+19 (AR transfectants of DU-145), ZR-75-1, MDA-MB-453, and T47D]; ...
N-Aryl-S,S-dimethylsulfimides 3(Ar = 4-NO(2)C(6)H(4)), 4 (Ar = Ph) and 5 (Ar = 4-Tol)react with Appel salt 1 to give the corresponding N-aryl-(4-chloro-5H-1,2,3-dithiazolylidene)benzenamines 8 (Ar = 4-NO(2)C(6)H(4)), 9 (Ar = Ph) and 10 (Ar = 4-Tol) in 84, 94 and 87% yields, respectively. The reaction proceeds in the absence of base and a proposed reaction mechanism is given.
Prostaglandin D2 (PGD2) and prostaglandin D2 receptor 2 (DP2) is known to be an important factor in androgenetic alopecia (AGA). However, the effect of PGD2 in human dermal papilla cells (hDPCs) is not fully understood. The function of PGD2-induced expression of the androgen receptor (AR), DP2, and AKT (protein kinase B) signal were examined by using real time-PCR (qRT-PCR), western blot analys...
SUMMARY Antibodies (Ab) recognizing G-protein coupled receptors, such as β 1 and β 2 adrenergic (anti-β 1-AR and anti-β 2-AR, respectively) and muscarinic cholinergic receptors (anti-M2-CR) may contribute to cardiac damage, however their role in chronic chagasic cardiomyopathy is still controversial. We describe that Trypanosoma cruzi-infected C3H/He mice show increased P and QRS wave duration,...
Rotational-tunneling spectra for Ar– (H2O)2 and Ar– (D2O)2 have been observed with the Balle– Flygare Fourier transform microwave spectrometer. The tunneling levels of the trimer appear to correlate with those of the water dimer. The ‘‘a’’ dipole transitions from the A1 1 and E states of Ar– (H2O)2 and A1 1 , B1 1 , and E states of Ar– (D2O)2 could be fit to a semirigid rotor Watson Hamiltonian...
Escherichia coli O157:H7 is a highly acid-resistant food-borne pathogen that survives in the bovine and human gastrointestinal tracts and in acidic foods such as apple cider. This property is thought to contribute to the low infectious dose of the organism. Three acid resistance (AR) systems are expressed in stationary-phase cells. AR system 1 is sigma(S) dependent, while AR systems 2 and 3 are...
To test the hypothesis that estrogen confers cardioprotection by suppressing the expression of beta-adrenoceptor (beta-AR), we first correlated the infarct size in response to ischemic insult and beta-AR stimulation with the expression of beta(1)-AR in sham, ovariectomized (Ovx) and estrogen replaced (Ovx + E(2)) rats. When beta-AR is being activated during ischemia, the infarct size was signif...
Differential Distribution of -Adrenergic Receptor Subtypes in Blood Vessels of Knockout Mice Lacking
-Adrenergic receptors ( -AR) are essential regulators of cardiovascular homeostasis. In addition to their prominent function in the heart, -AR are located on vascular smooth muscle cells, where they mediate vasodilating effects of endogenous catecholamines. In this study, we have investigated in an isometric myograph different types of blood vessels from mice lacking 1and/or 2-adrenergic recept...
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