We studied the association of breast cancer with the polymorphic polyglutamine repeat of the androgen receptor (AR) in 255 incident cases of breast cancer and 461 matched controls from the Quebec City metropolitan area. Women for whom the sum of both of the AR (CAG)n-repeats alleles is 39 or less (short-allele AR genotypes) have one-half the risk of breast cancer compared with women for whom th...

The aim of the present study was to compare the effects of three preferential (BRL 37344, SR 58611, CL 316 243) and a partial (CGP 12177) beta-adrenoceptor (beta(3)-AR) agonists on the contractility of ventricular strips sampled from various mammalian species including humans. In the human heart, all beta(3)-AR agonists tested decreased contractility by 40 to 60% below control with an order of ...

Upper Triassic rocks in northwestern Argentina preserve the most complete record of dinosaurs before their rise to dominance in the Early Jurassic. Here, we describe a previously unidentified basal theropod, reassess its contemporary Eoraptor as a basal sauropodomorph, divide the faunal record of the Ischigualasto Formation with biozones, and bracket the formation with (40)Ar/(39)Ar ages. Some ...

The Permian-Triassic boundary records the most severe mass extinctions in Earth's history. Siberian flood volcanism, the most profuse known such subaerial event, produced 2 million to 3 million cubic kilometers of volcanic ejecta in approximately 1 million years or less. Analysis of (40)Ar/(39)Ar data from two tuffs in southern China yielded a date of 250.0 +/- 0.2 million years ago for the Per...

We consider auctions in which the players have very limited knowledge about their own valuations. Specifically, the only information that a Knightian player i has about the profile of true valuations, θ∗, consists of a set of distributions, from one of which θ∗ i has been drawn. The VCG mechanism guarantees very high social welfare both in singleand multi-good auctions, so long as Knightian pla...

We demonstrate the existence of buried image-potential states at the interface between thick Ar films and a Cu(100) substrate. The electron dynamics of these solid-solid interface states, energetically located above the vacuum level in the band gaps of both materials, could be investigated with time-resolved two-photon photoemission for an Ar layer thickness up to 200 A. Relaxation on time scal...

The atmospheric Ar/N2 ratio is expected to be useful as a tracer of air-sea heat exchange, but this application has been hindered in part due to sampling artifacts. Here we show that the variability in δ(Ar/N2) due to thermal fractionation at the inlet can be on the order of 40–80 per meg, and we introduce the use of an aspirated solar shield that successfully minimizes such fractionation. The ...

On 30.14 March 1997 we observed the EUV spectrum of the bright comet C/1995 O1 (Hale-Bopp) at the time of its perihelion, using our EUVS sounding rocket tele-scope/spectrometer. The spectra reveal the presence H Ly β, O + , and, most notably, Argon. Modelling of the retrieved Ar production rates indicates that comet Hale-Bopp is enriched in Ar relative to cosmogonic expectations. This in turn i...

Electron yields from clean and oxydized Inconel 625 surfaces have been measured for H', H:, Hef, 0' and Ar+ ions at normal incidence in the energy range 1.5-40 keV. These measurements have been made under ultrahigh vacuum and the samples were freed of surface contaminants by bombarding with high doses of either 20 keV H l or 30 keV Ar+ ions. Differences in yields of oxydized versus clean surfac...