Alantolactone and isoalantolactone, main bioactive compounds that are present in many medicinal plants such as Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, have been found to have various pharmacological actions including anti-inflammatory, antimicrobial, and anticancer properties, with no significant toxicity. Recently, the anticancer activity of alant...

Microarray-based gene expression analysis holds promise of improving prognostication and treatment decisions for breast cancer patients. However, the heterogeneity of breast cancer emphasizes the need for validation of prognostic gene signatures in larger sample sets stratified into relevant subgroups. Here, we describe a multifunctional user-friendly online tool, GOBO (http://co.bmc.lu.se/gobo...

The effects of aqueous-methanol extract of Saussurea lappa Clarke root (Sl.Cr) was investigated against D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced hepatitis in mice. Co-administration of D-GalN (700 mg/kg) and LPS (1 microg/kg) significantly raised the plasma transaminase levels (ALT/AST) as compared to the control group (p < 0.05). Pretreatment of mice with different doses o...

conclusions the crude hydroalcoholic extract of burdock root was found to cause better outcomes in the healing process, acute inflammation, and fibrosis on the 7th, 14th, and 21st day postoperatively. objectives in this experimental study, 36 male wistar rats each weighting approximately 200 - 220 g were studied in six groups, each with 6 animals for 21 days. hydroalcoholic extract of burdock r...

In the present study immunopharmacological properties of hydroalcoholic extract of Saussurea lappa C.B. Clarke root have been investigated. After administration of extract in doses of 100 and 200 mg/kg body weight a significant increase in leukocyte count, spleen weight, phagocytic index and antibody secreting cells were noticed. Treatment with extract enhanced DTH reaction, which is reflected ...