The pharmacokinetic behaviour of an ampicillin/sulbactam (2:1) combination was studied after intramuscular administration of a single dose (20 mg/kg body weight: 13.33 mg/kg of ampicillin and 6.67 mg/kg of sulbactam) to six sheep and six goats. The objective was to determine whether there were differences between sheep and goats in the disposition profiles of ampicillin and sulbactam. The dispo...

STUDY DESIGN Systematic review. OBJECTIVE To establish the ability of the Orebro Musculoskeletal Pain Questionnaire (OMPQ) to predict outcome in patients with recent onset spinal pain. SUMMARY OF BACKGROUND DATA Psychosocial factors are believed to play a significant role in the development of a chronic pain problem. The OMPQ is a self-administered screening questionnaire that was developed...

OBJECTIVE To assess the relationship between lifestyle prior to the event and functional recovery at hospital discharge after acute stroke. DESIGN Cohort study. PATIENTS A sample of 191 patients with first stroke episode (87.4% ischaemic). METHODS Severity of the event at admission was measured by the Modified National Institutes of Health Stroke Scale. The Frenchay Activity Index was use...

BACKGROUND Gait analyses are an important tool to diagnose diseases or to measure the rehabilitation process of patients. In this context, sensor-based systems, and especially accelerometers, gain in importance. They are able to improve objectiveness of gait analyses. In clinical settings, there is usually a supervisor who gives instructions to the patients, but this can have an influence on pa...

The aim of the present study is to develop an accurate constitution diagnostic method based solely on the individual's physical characteristics, irrespective of psychologic traits, characteristics of clinical medicine, and genetic factors. In this paper, we suggest a novel method for diagnosing constitutional types using only speech and face characteristics. Based on 514 subjects, the area unde...

The aim of this study was to test the influence of different degrees of additional illumination on visual caries detection using the International Caries Detection and Assessment System (ICDAS). Two calibrated examiners assessed 139 occlusal surfaces of extracted permanent molars using a standard operation lamp with or without an additional headlamp providing three default brightness intensitie...

There is a need for brief screening instruments for autistic spectrum disorders (ASD) that can be used by frontline healthcare professionals to aid in the decision as to whether an individual should be referred for a full diagnostic assessment. In this study we evaluated the ability of a short form of the autism spectrum quotient (AQ) questionnaire, the 10 item AQ-10, to correctly classify indi...

Twenty-seven patients with advanced malignancies were given 200 mg of ketoconazole orally every 6 or 12 h. Blood samples were collected during these intervals and after the last dose to determine plasma concentrations and half-lives. The mean plasma concentrations measured after the initial dose were 1.7 +/- 1.1 microgram/ml at 2 h, 0.9 +/- 0.2 microgram/ml at 6 h, and 0.7 +/- 0.4 microgram/ml ...

Categorizing human diseases provides higher efficiency and accuracy for disease diagnosis, prognosis, and treatment. Disease-disease association (DDA) is a precious information that indicates the large-scale structure of complex relationships of diseases. However, the number of known and reliable associations is very small. Therefore, identification of DDAs is a challenging task in systems biol...

AIM To determine the separate effects of exercise amount and intensity on the rate of response for glucose and insulin variables, where rate of response was defined as the number of individuals with improvement in glucose and insulin values that was beyond the day-to-day variability of measurement. METHODS Participants were 171 sedentary, middle-aged abdominally obese adults who completed a 2...