The objective of the current study is to determine the effects of regular wrestling exercise oxidative DNA damage and antioxidant parameters. The findings of the current study have shown that 8-hydroxy-2'-deoxyguanosine (8-OHdG) obtained from wrestlers in basal status were significantly lower than those of sedentary (p = .001). In contrast, Nitric oxide (NO) and Paraoxonase-1 (PON1) were remark...

Regular physical activity may play a protective role against cardiovascular disease in adults, and paraoxonase activity may serve to mediate this effect. This study compared paraoxonase activity and that of other antioxidative agents in adolescent athletes compared with inactive youth. Paraoxonase level was 177.32 +/- 100.10 (U/L) in children with regular physical activity and 98.11 +/- 40.92 (...

s: 1. Aharoni, A. (2004) “Directed Evolution of Paraoxonases PON1 and PON3 for Bacterial Expression and Catalytic Specialization” First International Conference on "Paraoxonases Basic and Clinical Directions of Current Research" 22-24 April 2004, Michigan Union, University of Michigan, Ann Arbor, USA. 2. Sussman, J.L. (2004) “The 3D-Structure, Mechanism and Evolution of Serum Paraoxonases” 22-2...

The aetiology of ischemic heart diseases is mainly based on atherosclerosis coronary artery. Inflammation and oxidative reactions are initiating aggravating the illness resulting in pathological remodelling vasculaturze at site injury. Endothelium lining blood vessels participated reaction biochemically through releasing some proteins into circulatory system which further complicate condition. ...

Background: Paraoxonase-1 (PON1) is one of the HDL-associated proteins which contributes to the antioxidant properties of these lipoproteins. The aim of this pilot study was to evaluate the effect of the nutritional supplement ALAnerv® on serum PON1 activity in post-acute stroke patients undergoing rehabilitation. Methods: We enrolled 28 post-acute stroke patients and randomly divided them into...

BACKGROUND The circulating cholinesterases acetyl- and butyrylcholinesterase may be suppressed and subsequently released from the brain in acute bacterial meningitis. METHODS We report serum activities of acetylcholinesterase and butyrylcholinesterase in paired arterial and jugular venous samples from seven patients with acute bacterial meningitis and eight healthy controls. Paraoxonase 1, wh...

BACKGROUND AND OBJECTIVES The aim of this study was to investigate serum paraoxanase-1 (PON) activity, total oxidant status (TOS), total antioxidant status (TAS), and the oxidative stress index (OSI) in tinnitus; and to compare the results with data from healthy subjects. SUBJECTS AND METHODS A total of 114 subjects-54 patients with tinnitus and 60 healthy controls were enrolled in this study...

BACKGROUND Paraoxonase-1 (PON1) is one of the HDL-associated proteins which contributes to the antioxidant properties of these lipoproteins. The aim of this pilot study was to evaluate the effect of the nutritional supplement ALAnerv® on serum PON1 activity in post-acute stroke patients undergoing rehabilitation. METHODS We enrolled 28 post-acute stroke patients and randomly divided them into...

OBJECTIVES To examined whether serum paraoxonase (PON1) and arylesterase (ARE) activities are correlated with inflammatory biomarkers (procalcitonin and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS). METHODS This cross-sectional study was conducted at the Departments of Cardiology and Biochemistry, Uludag University School of Medicine, Bursa, Turk...

Statins (3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors), apart from lowering plasma cholesterol, modulate other processes involved in atherogenesis. Paraoxonase (PON), contained in plasma high density lipoproteins, protects plasma lipoproteins from oxidative damage and is a potentially atheroprotective enzyme. We investigated the effect of cerivastatin on oxidant-antioxidant balance...