Improved treatment outcomes for the endometrial cancer patient requires precision methods to investigate the biology of this disease and clinically relevant models to test treatment drugs. Hence, we applied a personalized platform to investigate whether in vitro and in vivo models could accurately predict effective treatment regimens. We successfully expanded ascites-derived tumor cells from an...

Pregnancy-associated plasma protein-A (PAPP-A) stimulates insulin-like growth factor (IGF) action through proteolysis of IGF-binding protein (IGFBP)-4. In experimental animals, PAPP-A accelerates ovarian tumor growth by this mechanism. To investigate the effect of PAPP-A in humans, we compared serum and ascites from 22 women with ovarian carcinoma. We found that ascites contained 46-fold higher...

Objective: The main objective of the present study was to explore contact-independent immune suppressive mechanisms by humoral factors in malignant ascites from ovarian carcinoma that target effector T cells. Methods: Flow cytometry was the main method used to detect T cell function as assessed by CFSE-proliferation rate, in the presence of different concentrations of ascites fluid. Cell-free a...

BACKGROUND Shifting dullness and fluid wave are two techniques commonly used to detect ascites. However, these may fail to detect moderate or minimal ascites. Ultrasonography is a good non-invasive method to detect ascites but may not be available in distant rural areas of India. We assessed the utility of the puddle sign and auscultatory percussion for detecting ascites. METHODS Sixty-six pa...

In rare instances, severe respiratory syncytial virus (RSV) infections of the lower tract can cause life-threatening extrapulmonary complications. this report, we describe 4 previously healthy, term and late-preterm infants admitted to PICU with failure due RSV bronchiolitis who developed necrotizing enterocolitis shortly after admission. All exhibited progressive abdominal distention, had typi...

background paracentesis is a common bedside therapeutic and diagnostic procedure that requires insertion of a catheter into the peritoneal cavity; however, lack of a specialized fixator for securing the catheter causes frequent catheter kinking and patient discomfort. objectives this study aimed to demonstrate the efficacy of a designed paracentesis fixator in reducing patient discomfort and pr...

the present study examined the antioxidant defense of glutamine on plasma and liver antioxidant status in broilers under phs with respect to changes in the levels of lipid peroxidation marker malondialdehyde (mda), total antioxidant status (tas) and the activities of anti peroxidative enzymes [superoxide dismutase (sod) and glutathione dependent antioxidant enzymes glutathione peroxidase (gpx)]...

the present study was designed to examine the anatomical parameters of the cardiopulmonary system, the function of venous blood gas parameters and the development of ascites incidence in two genetic line chickens. three hundred forty day-old chickens from two pure broiler breeder lines, which were different in their growth rate and susceptibility to ascites syndrome were obtained. the relative ...

Published data on 4-week-long administration of extra thyroxine (T4) in broiler breeder hens to alleviate the cold-induced ascites in their offspring suggested that long-term maternal hyperthyroidism would affect the gastrointestinal tract morphology. Broiler breeder hens (n=70) were reared in individual cages and allotted to control and hyperthyroid groups (five replicates of seven ...

Chyloperitoneum associated with nephrotic syndrome is rare clinical entity and characterized by milky ascites. The modalities for detection of chyloperitoneum are laboratory investigations and radiological images. Lipoprotein electrophoresis is useful for confirmation of the diagnosis with chyloperitoneum. Treating underlying disease is the most important in the management of these patients.