Anatomically and functionally defined neuron types are sometimes further classified into individual subtypes based on unique functional or molecular properties. To better understand how developmental programs controlling neuron type specification are mechanistically linked to programs controlling neuronal subtype specification, we have analyzed a neuronal subtype specification program that occu...

We demonstrated a tilted fiber Bragg grating (TFBG)-based modulated amplified spontaneous emission (ASE) source, followed by the broadband, continuous-wave (CW) mid-infrared laser generated intracavity difference-frequency generation (DFG). By flattening spectrum of ASE source during its power amplification and injecting another 1018 nm in optical parametric oscillation(OPO) cavity, nonlinear f...

L-Arginine plays a central role in the normal function of several organs including the immune system. It is metabolized in macrophages by inducible nitric oxide synthase to produce nitric oxide, important in the cytotoxic mechanisms, and by arginase I (ASE I) and arginase II (ASE II) to synthesize L-ornithine and urea, the first being the precursor for the production of polyamines needed for ce...

In this paper, we study the effects of different ASE noise models on the performance of turbo code (TC) decoders. A soft-decoding algorithm, the Bahl, Cocke, Jelinek, and Raviv (BCJR) decoding algorithm [1], is generally used in the TC decoders. The BCJR algorithm is a maximum a posteriori probability (MAP) algorithm, and is very sensitive to the noise statistics. The Gaussian approximation of ...

Understanding the genetic basis of gene regulatory variation is a key goal of evolutionary and medical genetics. Regulatory variation can act in an allele-specific manner (cis-acting) or it can affect both alleles of a gene (trans-acting). Differential allele-specific expression (ASE), in which the expression of one allele differs from another in a diploid, implies the presence of cis-acting re...

We used mice with targeted deletion of 25-hydroxyvitamin D-1 α-hydroxylase [1α(OH)ase(-/-)] to investigate whether 1,25(OH)2D3 deficiency results in male infertility mediated by 1,25(OH)2D3 or extracellular calcium and phosphorus. Male 1α(OH)ase(-/-) and their wild-type littermates fed either a normal diet or a rescue diet from weaning were mated at 6-14 wk of age with female wild-type mice on ...

BACKGROUND Real-time perfusion (RTP) contrast echocardiography can be used during adenosine stress echocardiography (ASE) to evaluate myocardial ischemia. We compared two different types of RTP power modulation techniques, angiomode (AM) and high-resolution grayscale (HR), with 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia. METHO...

One of the challenges toward electrically driven organic lasers is the huge optical loss associated with the contact of electrodes and organic gain medium in device. We demonstrated a significant reduction of the optical loss by using our newly developed conjugated polyelectrolytes (CPE) PPFN(+)Br(-) as interlayer between gain medium and electrode. The optically pumped amplified spontaneous emi...

BACKGROUND This study analyzed predictors of regular mammography performance in Korea. In addition, we determined factors affecting regular mammography performance in life-transition aged women by applying an attitude, social influence, and self-efficacy (ASE) model. MATERIALS AND METHODS Data were collected from women aged over 40 years residing in province J in Korea. The 178 enrolled subje...

The identification of germline variants predisposing to hereditary nonpolyposis colorectal cancer (HNPCC) is crucial for clinical management of carriers, but several probands remain negative for such variants or bear variants of uncertain significance (VUS). Here we describe the results of integrative molecular analyses in 132 HNPCC patients providing evidences for improved genetic testing of H...