We present a new continuous adjoint method for Aerodynamic Shape Optimization (ASO) using the Euler equations, which reduces the computational cost of the gradients by reducing the volume integral part of the adjoint gradient formula to a surface integral. The savings are particularly significant for three-dimensional ASO problems on general unstructured and overset meshes. In order to validate...

Our prediction that phase II of dipotassium hydrogen chromatoarsenate, K(2)[HCr(2)AsO(10)], is ferroelectric, based on the analysis of the atomic coordinates by Averbuch-Pouchot, Durif & Guitel [Acta Cryst. (1978), B34, 3725-3727], led to an independent redetermination of the structure using two separate crystals. The resulting improved accuracy allows the inference that the H atom is located i...

OBJECTIVES The arterial switch operation (ASO) has become the standard surgical procedure for transposition of the great arteries (TGA) or variants with an excellent early outcome. However, there are concerns regarding neopulmonary stenosis, neoaortic regurgitation (neoAR) associated with neoaortic root dilatation and coronary artery disease. METHODS A total of 220 early survivors of the ASO ...

Background Abnormal aortic arch geometry, in particular the ‘gothic arch’, has been associated with reduced exercise performance in patients with repaired aortic coarctation. Following the arterial switch operation (ASO) for transposition of the great arteries (TGA), the morphology of the aorta is also known to be abnormal, presenting with dilated aortic root and ‘gothic’ deformity of the aorti...

We introduce a flexible framework to specify problem solutions (outcomes) and preferences among them. The proposal combines ideas from answer-set programming (ASP), answer-set optimization (ASO) and CP-nets. The problem domain is structured into components. ASP techniques are used to specify values of components, as well as global (intercomponent) constraints among these values. ASO methods are...

Alternating Structure Optimization (ASO) is a recently proposed linear Multitask Learning algorithm. Although its effective has been verified in both semi-supervised as well as supervised methods, yet they necessitate taking external resource as a prerequisite. Therefore, feasibility of employing ASO to further improve the performance merely rests on the labeled data on hand proves to be a task...

The title compound, potassium silver tetra-niobium nona-oxide arsenate, K(0.8)Ag(0.2)Nb(4)O(9)AsO(4), was prepared by a solid-state reaction at 1183 K. The structure consists of infinite (Nb(2)AsO(14))(n) chains parallel to the b axis and cross-linked by corner sharing via pairs of edge-sharing octa-hedra. Each pair links together four infinite chains to form a three-dimensional framework. The ...

Mitochondrial defects can be caused by mutations in nuclear or mitochondrial DNA. Large deletion/duplication and point mutations are the two major types of mitochondrial DNA (mtDNA) mutations. Comprehensive molecular diagnosis requires the analysis of multiple point mutations. We developed an effective multiplex PCR/allele-specific oligonucleotide (ASO) method to simultaneously screen multiple ...

RNA modalities are developing as a powerful means to re-direct pathogenic pre-mRNA splicing events. Improving the efficiency of these molecules in vivo is critical as they move towards clinical applications. Spinal muscular atrophy (SMA) is caused by loss of SMN1. A nearly identical copy gene called SMN2 produces low levels of functional protein due to alternative splicing. We previously report...