This study investigated the antispasticity potential of Sativex in mice. Chronic relapsing experimental allergic encephalomyelitis was induced in adult ABH mice resulting in hind limb spasticity development. Vehicle, Sativex, and baclofen (as a positive control) were injected intravenously and the "stiffness" of limbs assessed by the resistance force against hind limb flexion. Vehicle alone cau...

Background: Spasticity is a motor disorder that appears as cause of upper and lower limb disability, frequently causing pain. IncobotulinumtoxinA (IncoA) has proved effective for treating diverse musculoskeletal pathologies, including spasticity spasticity-related Aims: The aim was to determine the efficacy IncoA treatment pain associated etiologies. Methods: Prospective, single-center study 30...

Spasticity is one of the major complaints of patients with spinal cord injuries. It has negative effects such as limitations in activities of daily living (ADLs), pain, fatigue, sleep disorders, instability, joint contractures, pressure ulcers, and infection, and decreases gait ability through changes in timing of gait-related muscle contraction and cocontraction [1,2]. Spasticity, also, is a m...

Spasticity and stroke: pathophysiology and management rules 2 ARC Publishing in the rheological properties and in the contractile soft tissue and musculoskeletal system (intrinsic hypertonia) are often associated with chronic spasticity and, in turn have been associated with increased spasticity. Signs and symptoms of spasticity: Spasticity signs include muscle stiffness or spasm, muscle spasms...

Spasticity is a common consequence after spinal cord injury (SCI) that affects 53-78 % of individuals with SCI (Maynard, Karunas, & Waring, 1990). Spasticity is defined as increased tonic stretch reflexes and exaggerated tendon jerks (Lance, 1980). Rehabilitation modalities, pharmacologic intervention and surgery are three main therapeutic techniques for spasticity management (Adams & Hicks, 20...

OBJECTIVE This educational paper aims to describe, in adult patients, the different aspects of muscle overactivity after a central nervous system lesion, including spasticity, spastic dystonia and spastic co-contraction, the assessment of their symptoms and consequences, and therapeutic options. DISCUSSION AND CONCLUSION Clinical evaluation involves the assessment of passive range of motion, ...

how to cite this article: barzegar m, sayadnasiri m, tabrizi a. epilepsy as a rare neurologic manifestation of oculodentodigitalis dysplasia. iran j child neurol 2012; 6(3): 39-43. oculodentodigitalis dysplasia (oddd) is an extremely rare inherited disorderinvolving the development of the face, eyes, teeth and limbs. in addition,some patients develop neurological problems mostly a spastic parap...

background:   many of the patients with tethered cord syndrome (tcs) are admitted because of neurological symptoms, while some are admitted because of their orthopedic, urologic, anorectal, and dermatologic manifestations.consequently, this study aimed to evaluate the importance of early diagnosis and treatment of tethered cord syndrome on patient outcome. methods: fourty-three patients who und...

We assessed the impact of videotape analysis on scoring of the Hypertonia Assessment Tool (HAT) that discriminates between hypertonia subtypes. The HAT was administered to 28 children with cerebral palsy (mean age 9 years, range 4-17 years, 61% male). HAT examinations were videotaped; scores were assigned before and after videotape review. Neurological examination provided the gold standard dia...

Cerebral palsy is the most common cause of spasticity and physical disability in children and spasticity is one of the commonest problems in those with neurological disease. The management of spasticity in children with cerebral palsy requires a multidisciplinary effort and should be started as early as possible. There are a number of treatments available for the management of spasticity. This ...