OBJECTIVE To investigate the serum levels of Interleukin (IL)-17 and eotaxin levels and the relationship between serum IL-17, eotaxin and pulmonary function in asthmatic patients with allergic rhinitis. METHODS Serum IL-17 and eotaxin levels in asthmatic patients with allergic rhinitis during attacking and remission and in healthy control subjects were measured using enzyme-linked immunosorbe...

Background The frequency of asthma increases in childhood and is associated with risk factors varying across age groups. aim our study was to assess the prevalence its first six years life. Methods Within scope Adana Pediatric Allergy Risk Factor (ADAPAR) birth cohort study, 203 infants that had experienced at least one wheezing attack during year life were followed for development until years....

The Shorter Oxford Dictionary defines ‘exacerbation’ as ‘an increase in the severity of a disease’dwhich does not imply reversibility or otherwise. However, we wonder how many chest physicians define exacerbation as ‘an acute and temporary deterioration in either symptoms or signs (and for the sophisticated, biomarkers)’ of asthma, chronic obstructive pulmonary disease (COPD) or whatever. We kn...

Remodeling of the airway wall occurs in adults with asthma, and reticular basement membrane (RBM) thickening is pathognomonic of the asthma process. To investigate whether RBM thickening is present in children with difficult asthma and comparable to that seen in adults with asthma, we used light microscopy to measure RBM thickness in plastic-embedded endobronchial biopsy sections from 19 childr...

OBJECTIVES To determine the oxidant - antioxidant imbalance in asthmatic children, by measuring the levels of malondialdehyde (MDA) as an oxidant marker of lipid peroxidation as well as antioxidant compounds like vitamin C, vitamin E and uric acid and to investigate whether their concentrations are associated with more severe asthma. METHODS This case controlled prospective study was conducte...

The role of smoking as potential risk factor, selection factor ("healthy smoker" effect) and modifying factor (severity) of asthma was studied in the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA). The analysis involved 200 adult asthmatic cases recruited in chest clinics, 265 nonasthmatic controls and 586 relatives of asthmatics ...

BACKGROUND The administration of inhaled corticosteroids and worldwide usage of several asthma guidelines have improved asthma mortality. Elderly patients with asthma show high mortality rates, and may have several comorbidities, including overlap with chronic obstructive pulmonary disease (COPD). Among patients showing asthma overlapped with COPD (asthma-COPD overlap syndrome; ACOS), mortality...

BACKGROUND Asthma is a common chronic disease among young adults, and several studies have reported increased mortality rates in patients with asthma. However, no study has described sudden unexpected death in a nationwide setting in patients with uncontrolled asthma. We defined uncontrolled asthma as a previous hospital admittance because of asthma (of any severity) or when asthma was consider...