High field asymmetric waveform ion mobility spectrometry (FAIMS) is well-established as a tool for separating peptide isomers (sequence inversions and post-translationally modified localization variants). Here, we demonstrate the FAIMS is able to differentiate cis and trans isomers of polyproline. Polyproline assumes an all-cis conformation-the PPI helix-in 1-propanol, and an all-trans conforma...

The chronic defibrillation energy requirement (DER) is believed to remain clinically stable in patients with defibrillators. Six patients (two with an epicardial and four with a nonthoracotomy system) were identified with a rise in their chronic DER, which eliminated a 10-J safety margin, thus necessitating a defibrillator lead system revision. The mean increase in DER was 14.7 +/- 4 J and was ...

This paper describes a retinal prosthetic device using a modified pulse frequency modulation (PFM) based photosensor with a standard CMOS technology. The output waveform of the PFM based photosensor is modified to stimulate retinal cells effectively. Two improvements are achieved. First modification is to restrict the maximum output pulse frequency to protect cells and also to shift photosensit...

a r t i c l e i n f o a b s t r a c t We investigate the enhancement of Kerr nonlinearities in an asymmetric coupled double quantum-well (CQW) by analyzing the nonlinear optical response. With the consideration of real parameters in AlGaAs-based CQWs, we indicate the possibility to obtain the giant Kerr nonlinearities with the cancellation of linear absorption simultaneously. We also reveal bot...

Liquid extraction surface analysis (LESA) is a surface sampling technique that allows electrospray mass spectrometry analysis of a wide range of analytes directly from biological substrates. Here, we present LESA mass spectrometry coupled with high field asymmetric waveform ion mobility spectrometry (FAIMS) for the analysis of dried blood spots on filter paper. Incorporation of FAIMS in the wor...

An increasing number of cardiac electrophysiologists are fortunate not to have endured the challenges of implanting monophasic waveform cardioverterdefibrillators (ICDs). With early technology, ICDs were routinely tested during the implantation procedure and then again before discharge, with a not-infrequent need for system revisions. With transvenous, high-output devices and biphasic shocks, t...

In the presented paper, a sensorless driver circuit is designed, constructed and tested to control two types of three-phase Switched Reluctance Motor (SRM). The presented control algorithm has three steps. In the first step, the SRM is controlled by an open-loop method. In the second step, mathematical model of the SRM phase, motor parameters and flux-current-rotor position relation are used in...

The apparent advantages of Multilevel Inverter (MLI) topologies in handling medium and high power with less loss switching lower harmonic distortion an output voltage waveform makes it better than the conventional inverter. However, MLI utilize a large number DC supplies semiconductor devices. They also have higher value total standing (TSV). Moreover, capacitor balancing problems, self-voltage...

materials and methods in a double blind randomized trial study, 100 patients undergoing elective cardiac surgery were randomized to using heparinized (n = 50) or non-heparinized (normal) saline flush (n = 50) to maintain patency of arterial catheter after operation. indwelling arterial catheters were checked daily for acceptable arterial waveform for three days as primary outcome measures. resu...