Atherosclerosis of lower extremity is often accompanied by thrombosis and plaque injury. Currently, there a lack comprehensive hemodynamics study that combines platelet activation related to injury in atherosclerosis. Thus, we first analyze the mechanism further investigate effects stenosis hematocrit through hemodynamic results. An Euler–Euler method used for mixed fluid containing red blood c...

Coronary artery disease (CAD) is defined as myocardial damage developing a result of its organic and functional changes, leading to impaired blood flow through the coronary arteries. An important pathogenetic component CAD atherosclerosis. Currently, key aspects molecular relationship between inflammation atherosclerosis are being actively studied, immunometabolic theory discussed, along with a...

Atherosclerosis is the main cause of cardiovascular disease, and preventing the progression of atherosclerosis is therefore important. However, in atherosclerotic high-risk patients, the conventional management of traditional risk factors is insufficient to prevent the development of atherosclerosis. Recent studies have shown that proinflammatory cytokines, such as interleukin-6 (IL-6), play a ...

This study investigated whether coronary atherosclerosis was different from aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Atherosclerotic lesions were immunohistochemically stained by using a monoclonal antibody for rabbit macrophages (RAM-11) and a monoclonal antibody for muscle actin (HHF35) and were also subjected to conventional staining. The areas of the major lesion...

objective(s): in this study, for the first time, mf59 adjuvant was used to develop a cholesteryl ester transfer protein (cetp) vaccine. the efficacy of the vaccine was compared with the efficacy of cetp vaccine formulated with alum/cpg, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. materials and methods: tetanus toxoid- cetp peptide (tt-cetp) was mixe...

Factors which are known to be associated with cerebral atherosclerosis were evaluated in Nigerian Africans. Of 465 autopsied adult Nigerians, 62 (13%) had cerebral atherosclerosis. The frequency and severity of atherosclerosis among Nigerians with hypertension, particularly male subjects, were higher than in normotensives. Although there was a similar frequency of hypertension among autopsied N...

Atherosclerosis, an inflammatory process that selectively affects arteries, is highly prevalent in human. Thrombo-occlusive complications of atherosclerosis, including stroke and myocardial infarction, are becoming major causes of morbidity and mortality in the industrialized world. Atherosclerosis develops in response to local endothelial injuries. Endothelial dysfunction and cell loss are pro...

Atherosclerosis is a complicated disorder and largely attributable to dyslipidaemia and chronic inflammation. Despite therapeutic advances over past decades, atherosclerosis remains the leading cause of mortality worldwide. Due to their capability of immunomodulation and tissue regeneration, mesenchymal stem cells (MSCs) have evolved as an attractive therapeutic agent in various diseases includ...

Atherosclerosis and cancer are the leading causes of death in industrialized society. Although atherosclerosis has been considered to be multi-factorial disease in which genetic, environmental, and other factors have been implicated, the gaps remain in our knowledge of the etiopathogenesis as well as features of atherosclerosis. However, Numerous data suggested that the some characteristics of ...

the major lipoprotein classes are heterogenous. human serum high-density-lipoproteins (hdl) are separated into two major subfractions (hdl2, d=1.063-1.125 g/ml, hdl3, d=1.125-1.210 g/ml) by a simple double precipitation method. there was a strong inverse relation between hdl-cholesterol (hdl-c) and subfractions hdl2-c and hdl3-c with atherosclerosis. this study demonstrated that hdl-c (p<0.001)...