A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and fenofibrate in tablet formulation. The separation was achieved by Luna C18 column and methanol:acetate buffer pH 3.7 (82:18 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detection was carried out at 248 nm. Retention time of atorvastatin calcium and feno...

In this prospective study, we examined the effect of atorvastatin treatment on baroreflex sensitivity (BRS) in subjects with type 2 diabetes. A total of 79 patients with type 2 diabetes with dyslipidaemia were recruited. A total of 46 subjects were enrolled to atorvastatin 10 mg daily and low-fat diet and 33 patients to low-fat diet only. BRS was assessed non-invasively using the sequence metho...

placebo group but not in the atorvastatin group. Compared with placebo, atorvastatin reduced median sPLA2 mass ( 32.1% versus 23.1%), sPLA2 activity ( 29.5% versus 19.2%), Lp-PLA2 mass ( 35.8% versus 6.2%), and Lp-PLA2 activity ( 24.3% versus 5.4%; P 0.001 for all). Atorvastatin reduced the hazard of death associated with elevated sPLA2 mass and activity by 50%. Conclusions—sPLA2 mass independe...

Contrast-induced nephropathy (CIN) is an iatrogenic acute renal failure occurring following the intravascular injection of iodinated radiographic contrast medium. However, the regulatory mechanisms for CIN remain to be fully elucidated. The present study aimed to investigate whether atorvastatin protects against CIN via anti‑apoptotic effects by the upregulation of Hsp27 in vivo and in vitro. T...

Hepatic fibrosis is one of the common pathological features of chronic liver disease. Atorvastatin and naltrexone previously showed a beneficial effect on hepatic fibrosis. In the present study, we compared the effect of atorvastatin and naltrexone on a rat model of hepatic fibrosis induced by BDL. Methods: This study was carried out on 4 groups each of 10 albino rats; Group 1: Sham operated gr...

BACKGROUND AND PURPOSE Treatment with atorvastatin (80 mg) in stroke secondary prevention for patients with prior intracranial hemorrhage (ICH) has been associated with a higher frequency of ICH. The aim of this study was to determine whether 20 mg/day atorvastatin is linked to stroke recurrence in Chinese ischemic stroke patients with prior ICH. METHODS A single-center retrospective cohort s...

BACKGROUND Elevated serum levels of growth differentiation factor-15 (GDF-15) are associated with type 2 diabetes. Therefore, the effects of atorvastatin on metabolic parameters and GDF-15 levels in patients with type 2 diabetes and dyslipidemia were evaluated. METHODS In this prospective randomized trial from February 2013 to March 2014, 50 consecutive type 2 diabetic patients with a low den...

OBJECTIVES The objective of this study was to evaluate whether the regressive effects of aggressive lipid-lowering therapy with atorvastatin on coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) are generalized for other statins in multicenter setting. BACKGROUND A previous single-center study reported beneficial regressive effects of atorvastatin in patients with ACS ...

Angiotensin-converting enzyme inhibitors (ACEI) and statins are widely used in patients with coronary artery disease (CAD). Our aim was to compare changes in glomerular filtration rate (GFR) over time in subjects with stable CAD according to atorvastatin dose and concomitant use of ACEI. We studied 78 men with stable CAD referred for an elective coronary angiography who attained the then-curren...

Endothelial function is known to predict cardiovascular disease. The aim of the present study was to examine whether endothelial function in smokers with normal cholesterol levels could be normalized by treatment with 80 mg of atorvastatin in comparison with a control group. Healthy smokers (n=20) and non-smokers (n=20) were randomized to receive 80 mg of atorvastatin or placebo in an open rand...