نتایج جستجو برای: atovaquone
تعداد نتایج: 456 فیلتر نتایج به سال:
BACKGROUND Amongst the Plasmodium species in humans, only P. vivax and P. ovale produce latent hepatic stages called hypnozoites, which are responsible for malaria episodes long after a mosquito bite. Relapses contribute to increased morbidity, and complicate malaria elimination programs. A single drug effective against hypnozoites, primaquine, is available, but its deployment is curtailed by i...
Both apicomplexan parasites Toxoplasma gondii and Plasmodium falciparum lack type I NADH dehydrogenases (complex I), but instead encode alternative (type II) NADH dehydrogenases, which are absent in mammalian cells and are thus considered as promising antimicrobial drug targets. The quinolone-like compound 1-hydroxy-2-dodecyl-4(1)quinolone (HDQ) was recently 5 described as a high affinity inhib...
BACKGROUND Human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) have experienced a dramatic decrease in Pneumocystis carinii pneumonia (PCP), necessitating reassessment of clinical guidelines for prophylaxis. METHODS A simulation model of HIV infection was used to estimate the lifetime costs and quality-adjusted life expectancy (QALE) for...
Hydroxy-naphthoquinones are competitive inhibitors of the cytochrome bc(1) complex that bind to the ubiquinol oxidation site between cytochrome b and the iron-sulfur protein and presumably mimic a transition state in the ubiquinol oxidation reaction catalyzed by the enzyme. The parameters that affect efficacy of binding of these inhibitors to the bc(1) complex are not well understood. Atovaquon...
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