Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...

In determining public transport rates, it is necessary to compare the value of Ability Pay (ATP) and Willingness (WTP) for Soekarno-Hatta Airport Train service users pay a sum money services facilities they receive. The purpose this research analyze ATP WTP users. method collecting data online all respondents who have used service. obtained were then processed analyzed obtain results characteri...

The determination of Kereta Rel Listrik (KRL) rates needs to consider the value Ability Pay (ATP) and Willingness (WTP) service users spend a certain amount money for services they get. purpose this research was determine KRL across Bogor-Jakarta Kota. method collecting data online is by giving questionnaires respondents who use cross obtained were then analyzed information about individual cha...

Abstract The rising incidence of allergic disease is a public health challenge needing novel interventions. Mast cell activation by IgE an established feature allergy, but fundamental aspects IgE-induced signaling remain unclear. Prior data from our lab testing the effects fluoxetine on IgE-driven mast function indicated role for purinergic receptor P2X3. P2X3 ATP-activated cationic channel mos...

Diabetes Mellitus (DM) is characterized by increased blood glucose levels. It generally caused the pancreas' inability to produce insulin due cell damage or resistance. Due inhibition of adenosine triphosphate (ATP) production, which essential for secretion, one clinical pathology this complication secretion dysfunction. Common methods sugar diagnostics cannot distinguish mitochondrial diabetes...

FoF1-ATP synthases are ubiquitous membrane-bound, rotary motor enzymes that can catalyze ATP synthesis and hydrolysis. Their enzyme kinetics controlled by internal subunit rotation, substrate product concentrations, mechanical inhibitory mechanisms but also the electrochemical potential of protons across membrane. Single-molecule Forster resonance energy transfer (smFRET) has been used to detec...

Studies argue in favor of hydrogen sulfide (H2S) as the next potent therapeutic agent for neurodegenerative diseases. In present study, we investigated effect long term treatment with NaHS (as donor H2S) on induction and progress 6-hydroxydopamine (6-OHDA) -induced Parkinsonism rat. The 6-OHDA was injected into medial forebrain bundle right hemisphere by stereotaxic surgery. Behavioral tests tr...

Aims: Antipsychotic drugs are known to be commonly associated with sexual dysfunction. The aim of this study investigate the effects sertindole, asenapine and ziprasidone on serotonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) potassium chloride (KCl)-induced contractions isolated vas deferens in mice.
 Study design: All were administered intraperitoneally (i.p.) a volume 0.1...