Leukocytoclastic vasculitis (LCV) is an immune-complex mediated inflammation of dermal capillaries and venules that can occur after infections, drugs, autoimmune disorders, neoplasms, or idiopathically. We present the case a 59-year-old male who was treated with ceftriaxone for abscess, S. aureus cellulitis, osteomyelitis his right second toe. Biopsy confirmed diagnosis LCV symptoms resolved di...

Acute pericarditis, or inflammation of the pericardial sac, is a clinical condition which can often be attributed to variety underlying etiologies, including infection, autoimmune disease, trauma, and malignancy. While viral infections are commonly implicated in etiology bacteria known associated with pericarditis include staphylococcus species, streptococcal tuberculosis, children, Haemophilus...

Human peripheral demyelinating diseases, such as Guillain-Barré syndrome (GBS), are characterized by inflammation and demyelination in the peripheral nervous system. Similarities in the pathology between GBS and the animal model of experimental autoimmune neuritis (EAN) indicate that autoimmune responses are involved in both diseases. This article summarizes the general aspects of the EAN model...

Intravenous human immunoglobulins dominate in the treatment of autoimmune neuropathies. We introduce intrathecal application as a new option for experimental autoimmune neuritis in Lewis rats. After immunisation with neuritogenic P2 peptide, we show a therapeutic and preventive effect of intrathecal human immunoglobulins (5-40mg/kg) on clinical and electrophysiological neuritis signs. Histology...

Research into the molecular and cellular underpinnings of autoimmunity advances our understanding of immune functions and the role inflammation plays inmediating many of the symptoms of the multitude of autoimmune diseases. This knowledge serves as the foundation for identifying potential targets for treatment and developing novel therapies to prevent, modulate, and ultimately cure autoimmune d...

Lymphocytic adrenal medullitis characterized by inflammation and atrophy in the medulla of the bilateral adrenal glands was observed in an 18-month-old male laboratory beagle dog. It might be that the present lymphocytic adrenal medullitis is an autoimmune-mediated disease as the histological characteristics are consistent with an autoimmune pathogenesis. However, the actual cause remains uncle...

A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the  pro-inflammatory...

Bone remodeling is a lifelong process in vertebrates that relies on the correct balance between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and fracture risk are implicated in inflammatory autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and systemic lupus erythematosus. The network of inflammatory cytokines pr...