an 11-year-old female patient with autoimmune hepatitis (aih) was referred to our rheumatology clinic due to her current musculoskeletal manifestations. the patient had been diagnosed with aih 3 months previously, based on jaundice and impaired liver function tests, and she had been treated with low-dose prednisolone and azathioprine. she presented with malaise, arthritis, a malar rash on the f...

of retropharyngeal abscess or bony destruction. Sputum was negative for acid-fast bacilli on microscopy and culture. The results of blood cultures were negative. No other organism was seen on microscopy or cultured from the fluid aspirated from the neck. Treatment with azathioprine was stopped and prednisolone was continued at a dose of 15 mg a day. Treatment with daily intramuscular streptomyc...

The use of thiopurines as immunosuppression for the treatment of refractory or chronic active inflammatory bowel disease is established for both Crohn's disease and ulcerative colitis. Nevertheless, many questions remain concerning the optimal treatment regimens of azathioprine, 6-mercaptopurine and thioguanine. We will briefly summarize dose recommendations, indications for thiopurine therapy ...

The carcinogenicity of azathioprine was evaluated in weaning female noninbred Sprague-Dawley rats by feeding it in the diet. Due to toxicity, the dose had to be changed during the course of the experiments and ranged from 0.015 to 0.04% of the diet by weight. In the first experiment, the estimated maximal cumulative consumption of azathioprine was 1.5 g/rat. Of the 14 rats evaluated, six develo...

A case of biopsy-proven sarcoidosis with pleural and lung parenchymal involvement is reported. The resolution of neutrophilia and other disease manifestations with azathioprine points towards sarcoidosis being the probable cause. GG, 45 years old male, presented with fever and right-sided chest pain with biochemical features of granulomatous hepatitis and apparently unexplained leucocytosis. Az...

BACKGROUND AND AIM The immunosuppressive properties of 6-mercaptopurine and its parent compound azathioprine are mediated by their intracellular metabolism into active 6-thioguanine (6-TG) metabolites. Measurement of erythrocyte 6-TG metabolite levels has been proposed as a useful clinical tool for assessing treatment efficacy in patients with inflammatory bowel disease (IBD). AIM The purpose...

A simple, economical, precise and fast visible spectrophotometric method has been developed for the determination of Azathioprine in tablet dosage form. Developed method is based on the formation of extractable colored complex of drug with colouring agent Indigo Carmine and Methyl orange. A wavelength maximum was found to be 683.7 nm and 566 nm. The concentration range of 15-50 μg mL-1 with of ...

A 52-year-old man developed therapy-related acute myeloid leukemia (AML) following prolonged immunosuppression with azathioprine for polymyositis. Karyotypic analysis showed deletions of the short arm of chromosome 7 and the long arm of chromosome 5. The importance of recognizing this potential complication while treating benign rheumatological and immunological diseases with purine analogues l...

Myelosuppression is an important and potentially lethal complication of azathioprine treatment. The blood count has been reviewed in all patients treated with azathioprine for inflammatory bowel disease over 27 years in one hospital. Altogether 739 patients (422 with Crohn's disease, 284 with ulcerative colitis, and 33 with indeterminate colitis) were treated with 2 mg/kg/day azathioprine for a...