Acne pathogenesis has recently been linked to decreased nuclear FoxO1 levels and increased mTORC1 activity. This hypothesis postulates that antiacne agents either enhance nuclear FoxO activity or inhibit mTORC1. Benzoyl peroxide (BPO), by activation of oxidative stress-inducible kinases, increases nuclear FoxO levels promoting Sestrin3-mediated AMPK activation. Furthermore, BPO-derived ROS may ...

Melasma is a common acquired hyperpigmentation disorder disproportionately affecting women of color. Though its cause remains unknown, several predisposing risk factors have been identified. Our investigation sought to better define racial and ethnic differences in factors, treatment patterns, incidence melasma the US through large case-control analysis. We queried TriNetX database representing...

Medicinal plants are of great relevance with endless pharmaceutical and therapeutic properties. They source wide array secondary metabolites or bioactive compounds/phytochemicals (phenols, alkaloids, flavonoids, terpenoids, tannins, steroids saponins) which capable discharging numerous biological functions (antimicrobial, antioxidant, antiviral, antifungal, anti-fibrotic, immune-modulatory, cyt...

Abstract. Ozonolysis of fatty acid monolayers was studied to understand the fate organic-coated aerosols under realistic atmospheric conditions. Specifically, we investigated effects temperature and salinity on degradation oleic at air–water interface persistence aged surfactant film surface. The presence a residual is importance, as surface affect physical properties droplets because role they...

Arabidopsis EARLI-type hybrid proline-rich proteins (HyPRPs) consist of a putative N-terminal secretion signal, a proline-rich domain (PRD), and a characteristic eight-cysteine-motif (8-CM). They have been implicated in biotic and abiotic stress responses. AZI1 is required for systemic acquired resistance and it has recently been identified as a target of the stress-induced mitogen-activated pr...

The research was performed to study the simultaneous detection of a homologous series of α , ω -dicarboxylic acids (C2-C10), oxalic, malonic, succinic, glutaric, adipic, pimelic, suberic, azelaic, and sebacic acids, with capillary electrophoresis using indirect UV detection. Good separation efficiency in 2,6-pyridinedicarboxylic acid as background electrolyte modified with myristyl trimethyl am...

Background: Acne vulgaris is the most common condition encountered in dermatologic practice. Recent literature suggests racial and ethnic difference in the sequelae of acne complications with post acne hyperpigmentation topping the list. Therapeutic goals include promoting degradation of melanosomes and inhibiting their formation. Thus it is a challenge to treat patients of darker skin and find...