The single most commonly used marker to identify B-cell lymphomas is CD20. Certain types of B-lineage lymphomas are characteristically negative for CD20, however. These include plasmablastic lymphoma, HHV8+ primary effusion lymphoma (and its extracavitary or solid variant), B lymphoblastic lymphoma/leukemia and ALK+ diffuse large B-cell lymphoma. On encountering one of these high grade lymphoma...

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous category of nodal and extranodal mature T-cell lymphomas. PTCL-NOS is a highly aggressive lymphoma, and its prognosis is poorer than those of aggressive B-cell lymphoma such as diffuse large B-cell lymphoma(DLBCL). Current standard chemotherapies for aggressive B-cell lymphoma, such as CHOP, are the commonly used ...

Activation-induced cytidine deaminase (AID) induces somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion in B-lymphocytes. Here we report for the first time the expression of AID in healthy human B-lymphocytes and in B-cell non-Hodgkin lymphomas (B-NHL). AID mRNA expression in humans is restricted to the CD19(+)CD38(+)IgD(-) germinal center cells, na...

Note 3q27 rearrangements occur in distinct clinicopathological entities of B-cell non Hodgkin lymphoma (NHL), including diffuse large cell lymphoma (DLCL), follicle centre cell lymphoma (FCCL) and marginal zone B-cell lymphoma (MZBCL) in the REAL classification; very rare cases were also reported with mantle cell lymphoma and chronic lymphocytic leukemia. 3q27 breaks are usually, but not invari...

Indolent lymphomas are a markedly heterogeneous group of lymphoproliferative disorders including B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma, lymphoplasmacytoid lymphoma, follicular lymphoma, mantle cell lymphoma and mucosa-associated lymphoid tissue (MALT) lymphoma. The molecular pathophysiology of indolent lymphoma is characterized by distinct genetic pathways which selecti...

Primary cutaneous CD30+ T cell lymphoma is rare lymphoma originally in and confined to the skin. These lymphomas usually present as a large solitary and often ulcerated nodule. Its prognosis is a good and has a good response to radiotherapy. We report a 34- year- old man who had primary cutaneous CD30+T cell lymphoma on his face, which presented as an ulcerated nodule.

Epigenetic alterations of gene expression are important in the development of cancer. In this study, we identified genes which are epigenetically altered in major lymphoma types. We used DNA microarray technology to assess changes in gene expression after treatment of 11 lymphoma cell lines with epigenetic drugs. We identified 233 genes with upregulated expression in treated cell lines and with...

Abstract Chemo-immunotherapy has improved survival in B-cell lymphoma patients, but refractory/relapsed diseases still represent a major challenge, urging for development of new therapeutics. Karonudib (TH1579) was developed to inhibit MTH1, an enzyme preventing oxidized dNTP-incorporation DNA. MTH1 is highly upregulated tumor biopsies from patients with diffuse large (DLBCL) and Burkitt lympho...