BACKGROUND Despite the increasing development of early intervention services for psychosis, little is known about their cost-effectiveness. We assessed the cost-effectiveness of Outreach and Support in South London (OASIS), a service for people with an at-risk mental state (ARMS) for psychosis. METHOD The costs of OASIS compared to care as usual (CAU) were entered in a decision model and exam...

Anticoagulant therapy is a major component in the management of acute coronary syndromes (ACS). Four anticoagulant agents are currently commercially available for ACS, namely unfractionated heparin (UFH), enoxaparin, bivalirudin and fondaparinux. We describe the advantages of fondaparinux and the reasons that have hampered its uptake into routine management of ACS. Fondaparinux was shown to be ...

OBJECTIVES Obstetric anal sphincter injuries (OASISs) are a devastating postpartum complication; reducing rates is paramount to improving quality of care. In Norway, implementation of a perineal protection program decreased the incidence of OASIS by 48%. We sought to assess impact on OASIS rates following a similar program. METHODS This institutional review board-approved, retrospective cohor...

OfTechnology . Rapid changes and discontinuities in business environment will challenge enterprises. Tochallenge sustainable growth, companies have to find out new business solutions. There willbe needed knowledge and value innovations by networks of companies to create these solutions. There is urgent need to increase productivity of the knowledge work. New tools, methods and environments are ...

OBJECTIVES A rise in obstetric anal sphincter injuries (OASIS) has been observed and a preventive approach, originating in Finland, has been introduced in several European hospitals. The aim of this paper was to systematically evaluate the evidence behind the 'Finnish intervention'. DESIGN A systematic review of the literature conducted according to the Preferred Reporting for Systematic Revi...

Obstetric anal sphincter injuries (OASIS) are infrequent complications resulting in limited teaching opportunities. Our objective was to assess resident experience and comfort level with the repair of complex obstetric lacerations, improve knowledge skillset, training model's effectiveness. A beef tongue model used simulate a fourth-degree laceration (Figure 1). An anonymous pre-simulation asse...

The prevention, detection and amelioration of adverse events feature prominently in oncology protocols, the detailed plans for conducting clinical trials of therapies for the treatment of cancer. This paper summarises a safety review of such protocols prior to implementing OaSiS, a decision support system (DSS) in oncology [11]. OaSiS, shortly to undergo preliminary field evaluation in an oncol...

With the recent rapid growth of the World Wide Web, the advent of commodity internet access via modems, and the slower but steady proliferation of mobile computing devices, more and more users are accessing internet services from computationally capable machines connected via low-speed communication links. While many such services only offer access to static, unchanging documents, the number of...

Alzheimer’s disease has become a major concern in the healthcare domain as it is growing rapidly. Much research been conducted to detect from MRI images through various deep learning approaches.However, problems of availability medical data and preserving privacy patients still exists. To mitigate this issue detection, we implement federated approach, which found be more efficient, robust, cons...