abstract background: research studies on reproductive mechanism of laboratory animals are essential for further advancement of assisted reproductive techniques (art). one of these studies includes the assessment of in-vitro development of pre-implantation embryos. the objective was to compare the cleavage rates and morphology of in-vivo formed 2 to 8 cell embryos and blastocysts with in-vitro c...

background: recently, embryonic stem (es) cells have become very important resources in basic medical researches. these cells can differetiate into derivatives of all primary germ layers. objectives: in order to isolate embryonic stem cells in vitro, the blastocyst were cultured and the morphological aspects, population doubling time, alkalin phosphatse and differentiation properties of the cel...

background: the application of luteal phase supplementation hormones to increase the implantation rate is on debate among researchers. objective: in this study, the morphological and morphometrical assessment of superovulated mice endometrium were investigated at window implantation period superovulated mice. materials and methods: female mice were superovualated then were mated with vasectomiz...

conclusions exposure to formaldehyde vapor can destroy testicular structure and decrease percentages of sperm count and progressive motility. the present study indicated that a reduction in the percentage of progressive motile sperm may be potentiated by noise (700-5700 hz) in the simultaneous exposure to formaldehyde and noise group. thus, it can be anticipated that simultaneous exposure to fo...

background: the uterus is a dynamic tissue responding to hormonal changes during reproductive cycles. as such, uterine stem cells have been studied in recent years. transcription factors oct4 and sox2 are critical for effective maintenance of pluripotent cell identity. objective: the present research evaluated the mrna expression of oct4 and sox2 in the uterine tissues of ovariectomized mice tr...

objective(s) there are some reports in recent years indicating that renal ischemia - reperfusion (ir) induces deleterious changes in remote organs such as liver. the aim of this study was to investigate whether leukocytes have a role on the induction of oxidative stress in liver after renal ir. materials and methods inbred mice in ir donor group were subjected to renal ir injury. in sham donor ...

PURPOSE To assess iris neovascularization by uveal puncture of the mouse eye and determine the role of angiogenic factors during iris neovascularization. METHODS Uveal punctures were performed on BalbC mouse eyes to induce iris angiogenesis. VEGF-blockage was used as an anti-angiogenic treatment, while normoxia- and hypoxia-conditioned media from retinal pigment epithelium (RPE) cells was use...

carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .control mice received similar quantities of olive oil. daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. the histologic e...

background: radiation therapy is an effective method used for treatment of many types of cancers. however, this method can cause unwanted side effects such as bone marrow suppression. in this study, the effect of oral administration of biogenic selenium nanoparticles (senps) on total and differentiated white cells profile of balb/c mice exposed to x-ray radiation was investigated and compared w...

objective: carthamus tinctorius l.(c. tinctorius) is used as a food additive but also has medicinal applications. the present work was designed to investigate its probable side effects on the histology and function of the kidney in the mice. materials and methods: sixty adult balb/c mice were randomly distributed into one control and three experimental groups. the control group received only di...