BACKGROUND Therapeutic angiogenesis by the administration of recombinant vascular endothelial growth factor (rVEGF) is a novel strategy for the treatment of ischemic disorders. rVEGF has been delivered as a protein, by plasmid DNA, and by genetically engineered cells with different pharmacokinetic and physiological properties. In the present study, we examined a new method for delivery of rVEGF...

INTRODUCTION Bile acid malabsorption (BAM) is a syndrome of chronic watery diarrhoea with excess faecal bile acids. Disruption of the enterohepatic circulation of bile acids following surgical resection is a common cause of BAM. The condition is easily diagnosed by the selenium homocholic acid taurine (SeHCAT) test and responds to bile acid sequestrants. Idiopathic BAM (IBAM, primary bile acid ...

Business process models (BPM) are widely used for specification of software systems, as the basis for model driven software development. Hence, it is crucial to ensure that these BPMs fulfill the requirements they have to comply with. These requirements may originate from various domains. Many may be considered non-functional requirements. They are affecting privacy, security, as well as compli...

We demonstrate that interferometric observations of the Mw6.6 Bam (Iran) earthquake on December 26, 2003 acquired by Envisat-ASAR can not only map surface displacements and constrain fault models, but can also be used for damage mapping using the coherence magnitude. The Bam earthquake was the deadliest earthquake in 2003. An estimated 30000 people were killed and 85% of the buildings in the ar...

Bladder replacement or augmentation is required in congenital malformations or following trauma or cancer. The current surgical solution involves enterocystoplasty but is associated with high complication rates. Strategies for bladder tissue engineering are thus actively sought to address this unmet clinical need. Because of the poor efficacy of synthetic polymers, the use of bladder acellular ...

Tuberous sclerosis complex human disease gene products TSC1 and TSC2 form a functional complex that negatively regulates target of rapamycin (TOR), an evolutionarily conserved kinase that plays a central role in cell growth and metabolism. Here, we describe a novel role of TSC1/2 in controlling stem cell maintenance. We show that in the Drosophila ovary, disruption of either the Tsc1 or Tsc2 ge...

The Willshaw model is asymptotically the most efficient neural associative memory (NAM), but its finite version is hampered by high retrieval errors. Iterative retrieval has been proposed in a large number of different models to improve performance in auto-association tasks. In this paper, bidirectional retrieval for the hetero-associative memory task is considered: we define information effici...

Near field acoustical signals from fireballs (ranges < 200 km), when detected by dense ground networks, may be used to estimate the orientation of trajectory a fireball (Pujol et al., 2005) as well fragmentation locations (Kalenda 2014; Edwards and Hildebrand, 2004). Distinguishing ballistic arrivals (from cylindrical shock fireball) generated (quasi-spherical sources) remains challenge, but ar...

abstract   earthquakes have been affected the human life since the dawn of time; however, the complexities of human societies and communications in the cities, intensify the deleterious effects of the earthquakes, that affect urban areas. hence, in emergency phase and reconstruction, attention to the basic needs and shelter provision are the most important activities but urban design also play ...

In normal individuals, the epithelium of the colon absorbs 1.5-2 l of water a day to generate dehydrated feces. However, in the condition of bile acid malabsorption (BAM), an excess of bile acids in the colon results in diarrhea. Several studies have attempted to address the mechanisms contributing to BAM induced by various bile acids. However, none have addressed a potential dysregulation of a...